| Gene Name | |
| HF Protein Name | O75746 |
| HF Function | BHK-21 |
| Uniprot ID | |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) |
| Host Factor (HF) Name in Paper | HeLa |
| Gene synonyms | Calcium-binding mitochondrial carrier protein Aralar1 (mitochondrial aspartate/glutamate carrier 1) |
| Ensemble Gene ID | AGC1 ARALAR1 |
| Ensemble Transcript | 8604 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | ENST00000422440.7 [O75746-1], ENST00000709717.1 [O75746-1], |
| MINT ID | hsa:9517 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | O75746 |
| PANTHER ID | 9606.ENSP00000388658 |
| PDB ID(s) | 603667, 612949, |
| pfam ID | PTHR45678:SF7, PTHR45678, |
| Drug Bank ID | 4P5X, 4P60, |
| ChEMBL ID | PF00153 |
| Organism | DB00128 |
| Virus Name | Japanese encephalitis virus |
| Virus Short Name | JEV |
| Order | Amarillovirales |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Japanese encephalitis virus |
| Host | Vertebrates |
| Cell Tropism | Neurons |
| Associated Disease | Encephalitis |
| Mode of Transmission | Sexual contact, blood, breast feeding |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_search.do?species=Japanese_encephalitis_virus |
| ICTV DB link | https://ictv.global/report/183/flaviviridae |
| Virus Host DB link |
| Paper Title | SLC25A12 inhibits Japanese encephalitis virus replication by interacting with the NS1 and enhancing the type I interferon response |
| Author's Name | You-qin Yin, Le-le Liu, Yu-ting Jiang, Jin-chao Xing, Wen-bao Qi, Li-hong Huang |
| Journal Name | Veterinary Microbiology |
| Pubmed ID | 39096789 |
| Abstract | Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic orthoflavivirus causing human encephalitis and reproductive disorders in pigs. Cell-intrinsic antiviral restriction factors are the first line of defense that prevent a virus from establishing a productive infection, while the molecular mechanism of the virus-host interaction is still not fully understood. Our in vitro experiments demonstrated that the Solute Carrier Family 25 Member 12 (SLC25A12) interacted with the JEV nonstructural protein 1 (NS1) and inhibited JEV replication. Furthermore, we showed that knockdown or knockout of SLC25A12 promoted JEV replication, while overexpression of SLC25A12 repressed viral replication. Finally, we demonstrated that SLC25A12 increased IRF7 mRNA levels, which promoted IFN-β expression and subsequently induced antiviral effects. Collectively, our study revealed that SLC25A12 interacted with NS1, inhibiting viral RNA synthesis and transcription and enhancing type I interferon induction for antiviral effects. |
| Used Model | HEK-293T |
| DOI | 10.1016/j.vetmic.2024.110199 |
