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Virus Details


VHFID10020

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name GAS6
HF Protein Name Growth arrest-specific protein 6
HF Function
Uniprot ID Q14393
Protein Sequence View Fasta Sequence
NCBI Gene ID 2621
Host Factor (HF) Name in Paper GAS6
Gene synonyms AXLLG
Ensemble Gene ID ENSG00000183087
Ensemble Transcript ENST00000327773.7 [Q14393-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001764, GO:0001786, GO:0001934, GO:0001961, GO:0003104, GO:0005102, GO:0005509, GO:0005576, GO:0005615, GO:0005737, GO:0005788, GO:0005796, GO:0006468, GO:0006909, GO:0007165, GO:0007166, GO:0007167, GO:0007596, GO:0009267, GO:0010628, GO:0010804, GO:0019064, GO:0019079, GO:0030674, GO:0030971, GO:0031093, GO:0031100, GO:0031589, GO:0032008, GO:0032148, GO:0032689, GO:0032692, GO:0032715, GO:0032720, GO:0032825, GO:0033028, GO:0033033, GO:0035457, GO:0035754, GO:0043027, GO:0043066, GO:0043277, GO:0044346, GO:0045860, GO:0045892, GO:0046718, GO:0046813, GO:0046827, GO:0048018, GO:0048146, GO:0050766, GO:0051897, GO:0070062, GO:0070168, GO:0070374, GO:0070588, GO:0071307, GO:0071333, GO:0071363, GO:0071466, GO:0072659, GO:0085029, GO:0097028, GO:0097241, GO:1900142, GO:2000117, GO:2000270, GO:2000352, GO:2000510, GO:2000533, GO:2000669,
MINT ID Q14393
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 600441
PANTHER ID PTHR24040:SF14;PTHR24040
PDB ID(s) 1H30, 2C5D, 4RA0, 5VXZ,
pfam ID PF12662, PF07645, PF00594, PF12661, PF00054, PF02210,
Drug Bank ID N.A.,
ChEMBL ID CHEMBL4804247
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Japanese encephalitis virus
Virus Short Name JEV
Order Amarillovirales
Virus Family Flaviviridae
Virus Subfamily N.A.
Genus Flavivirus
Species Japanese encephalitis virus
Host Vertebrates
Cell Tropism Neurons
Associated Disease Encephalitis
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link https://www.viprbrc.org/brc/vipr_search.do?species=Japanese_encephalitis_virus
ICTV DB link https://ictv.global/report/183/flaviviridae
Virus Host DB link

Publication Information

Paper Title GAS6 as a potential target to alleviate neuroinflammation during Japanese encephalitis in mouse models
Author's Name Peiyu Bian,#1 Haijun Zhang,#2 Chuantao Ye,#3 Chuanyu Luo,4 Hong Jiang,3 Yuan Wang,5 Yangchao Dong,5 Jing Yang,5 Fanglin Zhang,5 Xiaoming Wang,1 Ying Zhang,corresponding author3 Zhansheng Jia,corresponding author6 and Yingfeng Leicorresponding author5
Journal Name Journal of Neuroinflammation
Pubmed ID 39300526
Abstract Viral encephalitis is characterized by inflammation of the brain parenchyma caused by a variety of viruses, among which the Japanese encephalitis (JE) virus (JEV) is a typical representative arbovirus. Neuronal death, neuroinflammation, and breakdown of the blood brain barrier (BBB) constitute vicious circles of JE progression. Currently, there is no effective therapy to prevent this damage. Growth arrest specific gene 6 (GAS6) is a secreted growth factor that binds to the TYRO3, AXL, and MERTK (TAM) family of receptor tyrosine kinases and has been demonstrated to participate in neuroprotection and suppression of inflammation in many central nervous system (CNS) diseases which has great potential for JE intervention. In this study, we found that GAS6 expression in the brain was decreased and was reversely correlated with viral load and neuronal loss. Mice with GAS6/TAM signalling deficiency showed higher mortality and accelerated neuroinflammation during peripheral JEV infection, accompanied by BBB breakdown. GAS6 directly promoted the expression of tight junction proteins in bEnd.3 cells and strengthened BBB integrity, partly via AXL. Mice administered GAS6 were more resistant to JEV infection due to increased BBB integrity, as well as decreased viral load and neuroinflammation. Thus, targeted GAS6 delivery may represent a strategy for the prevention and treatment of JE especially in patients with impaired BBB.
Used Model bEnd.3,C8-D1A,neuro2a,BHK,AAV-293
DOI 10.1186/s12974-024-03225-1