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Virus Details


VHFID10025

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name P02778
HF Protein Name CXCL10
HF Function CXCL10
Uniprot ID N.A.
Protein Sequence View Fasta Sequence
NCBI Gene ID INP10 SCYB10
Host Factor (HF) Name in Paper Vero
Gene synonyms C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) [Cleaved into: CXCL10(1-73)]
Ensemble Gene ID 3627
Ensemble Transcript ENSG00000169245
KEGG ID Go to KEGG Database
Gene Ontology ID(s) hsa:4143,
MINT ID GO:0005102; GO:0005576; GO:0005615; GO:0006935; GO:0006954; GO:0007165; GO:0007166; GO:0007186; GO:0007189; GO:0007267; GO:0007517; GO:0008009; GO:0008015; GO:0008201; GO:0008284; GO:0008603; GO:0009897; GO:0010332; GO:0010818; GO:0010819; GO:0010996; GO:0016525; GO:0030593; GO:0033280; GO:0034605; GO:0042056; GO:0042118; GO:0042127; GO:0042981; GO:0045236; GO:0045662; GO:0045944; GO:0048248; GO:0051281; GO:0061844; GO:0070098; GO:0071222; GO:0090026; GO:0097398; GO:0098586; GO:0140374; GO:1901509; GO:1901740; GO:2000406
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 9606.ENSP00000305651
PANTHER ID 147310
PDB ID(s) PTHR12015:SF188, PTHR12015,
pfam ID 1LV9, 1O7Y, 1O7Z, 1O80, 8K2X,
Drug Bank ID PF00048,
ChEMBL ID DB11338;DB06116;DB04487
Organism CHEMBL3712964

Pathogen Information

Virus Name Japanese encephalitis virus
Virus Short Name JEV
Order Amarillovirales
Virus Family Flaviviridae
Virus Subfamily N.A.
Genus Flavivirus
Species Japanese encephalitis virus
Host Vertebrates
Cell Tropism Neurons
Associated Disease Encephalitis
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link https://www.viprbrc.org/brc/vipr_search.do?species=Japanese_encephalitis_virus
ICTV DB link https://ictv.global/report/183/flaviviridae
Virus Host DB link

Publication Information

Paper Title Interferon-stimulated gene 56 positively regulates Toll-like receptor 3-mediated CXCL10 expression in human renal proximal tubular epithelial cells
Author's Name Mayuki Tachizaki 1, Sho Sakamoto 2, Yuri Kobori 3, Yoshiya Asano 4, Shogo Kawaguchi 1, Kazuhiko Seya 1, Hiroshi Tanaka 5, Eiji Morita 2, Tadaatsu Imaizumi 4
Journal Name FEBS Open Bio
Pubmed ID 38923445
Abstract Viral infections in tubular epithelial cells lead to the production of inflammatory cytokines by innate immunity, causing tubulointerstitial nephritis. TLR3 recognizes viral infections and acts via the activation of interferon (IFN)/IFN-stimulated genes (ISGs). This study investigates the role of ISG56, a representative ISG, in TLR3 signaling in cultured human renal proximal tubular epithelial cells (hRPTECs). To this end, hRPTECs were stimulated by a synthetic TLR3 ligand, polyinosinic-polycytidylic acid (poly IC), recombinant human interferon-β [r(h)IFN-β] or Japanese encephalitis virus (JEV) infection and assayed for inflammatory cytokine mRNA expression by RT-qPCR, and protein expression via western blotting or ELISA. ISG56 was expressed by poly IC or r(h)IFN-β and IFN-β knockdown reduced poly IC-induced expression of ISG56 and CXCL10. Moreover, ISG56 knockdown reduced poly IC- or r(h)IFN-β-induced expression of CXCL10 at the same time as increasing JEV growth and reducing CXCL10 expression induced by JEV infection. Overall, TLR3 signaling induced IFN-β-dependent expression of ISG56 and CXCL10. We show that ISG56 possibly plays a critical role in antiviral immunity of hRPTECs by positive regulation of IFN-β-mediated CXCL10 expression downstream of TLR3.
Used Model hRPTECs
DOI 10.1002/2211-5463.13854