Virus Details


VHFID10095

Host Factor Information

Gene Name TNF-α
HF Protein Name Tumor Necrosis Factor Alpha
HF Function
Uniprot ID P01375
Protein Sequence View Fasta Sequence
NCBI Gene ID 7124
Host Factor (HF) Name in Paper TNF-α
Gene synonyms TNFA TNFSF2
Ensemble Gene ID ENSG00000232810
Ensemble Transcript ENST00000376122.3;ENST00000383496.4;ENST00000412275.2;ENST00000420425.2;ENST00000443707.2;ENST00000448781.2;ENST00000449264.3
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000976, GO:0001666, GO:0001774, GO:0001819, GO:0001891, GO:0001934, GO:0001937, GO:0002020, GO:0002037, GO:0002281, GO:0002439, GO:0002523, GO:0002637, GO:0002719, GO:0002876, GO:0002925, GO:0003009, GO:0003085, GO:0005125, GO:0005164, GO:0005576, GO:0005615, GO:0005886, GO:0006006, GO:0006954, GO:0006959, GO:0007254, GO:0007259, GO:0007623, GO:0008625, GO:0008630, GO:0009410, GO:0009615, GO:0009651, GO:0009750, GO:0009897, GO:0009986, GO:0010459, GO:0010573, GO:0010628, GO:0010629, GO:0010888, GO:0014823, GO:0019222, GO:0019722, GO:0030198, GO:0030316, GO:0030730, GO:0031334, GO:0031622, GO:0031642, GO:0031667, GO:0032715, GO:0032722, GO:0032724, GO:0032729, GO:0032731, GO:0032741, GO:0032755, GO:0032757, GO:0033138, GO:0033209, GO:0034116, GO:0034138, GO:0035900, GO:0036005, GO:0038177, GO:0042311, GO:0042802, GO:0043025, GO:0043065, GO:0043068, GO:0043122, GO:0043123, GO:0043242, GO:0043243, GO:0043406, GO:0043410, GO:0043491, GO:0043507, GO:0043525, GO:0043537, GO:0045071, GO:0045121, GO:0045429, GO:0045471, GO:0045598, GO:0045599, GO:0045662, GO:0045668, GO:0045672, GO:0045732, GO:0045760, GO:0045785, GO:0045840, GO:0045892, GO:0045893, GO:0045930, GO:0045944, GO:0045994, GO:0046325, GO:0046330, GO:0048018, GO:0048143, GO:0048566, GO:0048661, GO:0050729, GO:0050768, GO:0050796, GO:0050806, GO:0050807, GO:0050830, GO:0050890, GO:0050901, GO:0050966, GO:0050995, GO:0051044, GO:0051091, GO:0051092, GO:0051222, GO:0051384, GO:0051798, GO:0051897, GO:0051966, GO:0055037, GO:0060252, GO:0060557, GO:0060559, GO:0060664, GO:0060693, GO:0061044, GO:0061048, GO:0070374, GO:0070886, GO:0071222, GO:0071230, GO:0071300, GO:0071316, GO:0071346, GO:0071479, GO:0071677, GO:0071803, GO:0072577, GO:0072659, GO:0090324, GO:0090594, GO:0097191, GO:0097237, GO:0097421, GO:0097527, GO:0120190, GO:0140374, GO:0140460, GO:0150078, GO:0150129, GO:1900017, GO:1900222, GO:1901224, GO:1901647, GO:1902004, GO:1902065, GO:1902565, GO:1902894, GO:1902895, GO:1903078, GO:1903140, GO:1903347, GO:1903721, GO:1904646, GO:1904707, GO:1904996, GO:1904999, GO:1905038, GO:1905242, GO:1990268, GO:2000010, GO:2000272, GO:2000334, GO:2000343, GO:2000347, GO:2000351, GO:2000377, GO:2000573, GO:2001056, GO:2001234, GO:2001238, GO:2001240,
MINT ID P01375
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 191160;607507;610424;611162
PANTHER ID PTHR11471:SF23;PTHR11471
PDB ID(s) 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 4Y6O, 5M2I, 5M2J, 5M2M, 5MU8, 5TSW, 5UUI, 5WUX, 5YOY, 6OOY, 6OOZ, 6OP0, 6RMJ, 6X81, 6X82, 6X83, 6X85, 6X86, 7ASY, 7AT7, 7ATB, 7JRA, 7KP9, 7KPA, 7KPB, 7QLF, 7TA3, 7TA6, 8Z8M,
pfam ID PF00229,
Drug Bank ID DB00051, DB04956, DB05879, DB01427, DB05767, DB05513, DB11752, DB08904, DB00608, DB01407, DB05744, DB05758, DB06444, DB12140, DB00668, DB00005, DB05869, DB10770, DB10772, DB13751, DB06674, DB00065, DB05303, DB06495, DB05992, DB05218, DB09221, DB08910, DB05968, DB01411, DB00852, DB05207, DB05412, DB04297, DB05470, DB05017,
ChEMBL ID CHEMBL1825
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Japanese encephalitis virus
Virus Short Name JEV
Order Amarillovirales
Virus Family Flaviviridae
Virus Subfamily N.A.
Genus Flavivirus
Species Japanese encephalitis virus
Host Vertebrates
Cell Tropism
Associated Disease Encephalitis
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link https://www.viprbrc.org/brc/vipr_search.do?species=Japanese_encephalitis_virus
ICTV DB link https://ictv.global/report/183/flaviviridae
Virus Host DB link

Publication Information

Paper Title Japanese Encephalitis Virus exploits microRNA-155 to suppress the non-canonical NF-κB pathway in human microglial cells
Author's Name Meghana Rastogi 1, Sunit Kumar Singh 7
Journal Name Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Pubmed ID 32987149
Abstract Japanese Encephalitis Virus (JEV) is a single positive strand RNA virus, belongs to the Flaviviridae family. JEV is neurotropic in nature which accounts for 30-50% neurological, psychiatric sequelae and movement disorder, with 20-30% case fatality rate among children or elder population. JEV causes neuronal loss and microglial activation which leads to neuroinflammation. The microRNAs are the molecular switches, which regulate the gene expression post-transcriptionally. The microRNA-155 has been reported to be associated with CNS-related pathologies like, experimental autoimmune encephalitis, multiple sclerosis and amyotrophic lateral sclerosis. In the present study, we infected microglial cells with JEV, which resulted in the up-regulation of microRNA-155; quantified by real-time polymerase chain reaction. The gene target prediction databases revealed pellino 1 as a putative gene target for microRNA-155. The over-expression based studies of microRNA-155 mimics, scrambles, inhibitors, and cy3 negative control demonstrated the role of PELI1 in the regulation of the non-canonical NF-κB pathway via TRAF3. The luciferase assay showed the regulation of NF-κB promoter via microRNA-155 in JEV infected microglial cells. The suppression of NF-κB in JEV infected microglial cells led to the reduced expression of IL-6 and TNF-α. JEV exploits cellular microRNA-155 to suppress the expression of PELI1 in human microglial cells as a part of their immune evasion strategy.
Used Model CHME3,PS,BALB/C
DOI 10.1016/j.bbagrm.2020.194639