| Gene Name | hnrnp-k |
| HF Protein Name | Heterogeneous Nuclear Ribonucleoprotein K. |
| HF Function | |
| Uniprot ID | P61978 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3190 |
| Host Factor (HF) Name in Paper | HNRNP-K |
| Gene synonyms | HNRPK |
| Ensemble Gene ID | ENSG00000165119 |
| Ensemble Transcript | ENST00000351839.7 [P61978-1];ENST00000360384.9 [P61978-1];ENST00000376263.8 [P61978-2];ENST00000376281.8 [P61978-2];ENST00000457156.6 [P61978-3];ENST00000704004.1 [P61978-3];ENST00000704005.1 [P61978-2];ENST00000704006.1 [P61978-1];ENST00000704011.1 [P61978-2];ENST00000704051.1 [P61978-1];ENST00000704052.1 [P61978-1];ENST00000704053.1 [P61978-1];ENST00000704057.1 [P61978-2];ENST00000704058.1 [P61978-1];ENST00000704059.1 [P61978-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000398, GO:0000785, GO:0002102, GO:0003677, GO:0003723, GO:0003729, GO:0005634, GO:0005654, GO:0005737, GO:0005925, GO:0006357, GO:0006396, GO:0007165, GO:0010494, GO:0010988, GO:0016020, GO:0019904, GO:0031048, GO:0042802, GO:0042995, GO:0043066, GO:0045296, GO:0045892, GO:0045944, GO:0048024, GO:0048025, GO:0048260, GO:0060816, GO:0070062, GO:0071013, GO:1902165, GO:1905599, GO:1990904, |
| MINT ID | P61978 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 600712;616580 |
| PANTHER ID | PTHR10288 |
| PDB ID(s) | 1J5K, 1KHM, 1ZZI, 1ZZJ, 1ZZK, 7CRE, 7CRU, 7RJK, 7RJO, |
| pfam ID | PF00013, PF08067, |
| Drug Bank ID | DB11638, DB12695, |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Japanese encephalitis virus |
| Virus Short Name | JEV |
| Order | Amarillovirales |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Japanese encephalitis virus |
| Host | Vertebrates |
| Cell Tropism | |
| Associated Disease | Encephalitis |
| Mode of Transmission | Sexual contact, blood, breast feeding |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_search.do?species=Japanese_encephalitis_virus |
| ICTV DB link | https://ictv.global/report/183/flaviviridae |
| Virus Host DB link |
| Paper Title | Proteomic analyses identify intracellular targets for Japanese encephalitis virus nonstructural protein 1 (NS1) |
| Author's Name | Peng Wang 1, Xinze Liu 1, Qi Li 1, Jue Wang 1, Wenke Ruan 3 |
| Journal Name | Virus Research |
| Pubmed ID | 34175344 |
| Abstract | Japanese encephalitis is a zoonotic disease caused by Japanese encephalitis virus (JEV). JEV nonstructural protein 1 (NS1) is involved in many crucial biological events during viral infection and immune suppression. To investigate the role of JEV NS1 in virus-infected cells, the molecules with which it interacts intracellularly were screened with a pull-down assay and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The interaction between heterogeneous nuclear ribonucleoprotein K (hnRNP K), vimentin and NS1 were verified with coimmunoprecipitation and confocal assays. Our results show that JEV NS1 interacts with vimentin, hnRNP K and colocalizes with cellular vimentin and hnRNP K. Furthermore, our results demonstrate that the expression of vimentin and hnRNP K were up-regulated in both NS1-transfected and JEV-infected cells. Knocking down vimentin and hnRNP K reduced viral replication while conversely, over-expression of vimentin and hnRNP K improved viral replication, suggesting an important role for this protein in the viral life cycle. Also, We found that vimentin also interacted with hnRNP K after overexpression of NS1 or JEV infection. These findings provide insight into the molecular mechanism of JEV replication and highlight the key role the NS1 in JEV infection. |
| Used Model | Bhk 21 and pk16 |
| DOI | 10.1016/j.virusres.2021.198496 |
