| Gene Name | ATPase |
| HF Protein Name | Adenosine Triphosphatase. |
| HF Function | |
| Uniprot ID | P00846 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 4508 |
| Host Factor (HF) Name in Paper | ATPase |
| Gene synonyms | ATP6 ATPASE6 MTATP6 |
| Ensemble Gene ID | ENSG00000198899 |
| Ensemble Transcript | ENST00000361899.2 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005739, GO:0005743, GO:0015078, GO:0015986, GO:0042776, GO:0045259, GO:0045263, GO:0055093, |
| MINT ID | P00846 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 256000;500003;500006;500010;500011;500015;516060;535000;551500 |
| PANTHER ID | PTHR11410;PTHR11410:SF0 |
| PDB ID(s) | 8H9F, 8H9J, 8H9M, 8H9Q, 8H9S, 8H9T, 8H9U, 8H9V, 8KHF, 8KI3, |
| pfam ID | PF00119, |
| Drug Bank ID | DB00783, DB13952, DB13953, DB13954, DB13955, DB13956, |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Japanese encephalitis virus |
| Virus Short Name | JEV |
| Order | Amarillovirales |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Japanese encephalitis virus |
| Host | Vertebrates |
| Cell Tropism | |
| Associated Disease | Encephalitis |
| Mode of Transmission | Sexual contact, blood, breast feeding |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_search.do?species=Japanese_encephalitis_virus |
| ICTV DB link | https://ictv.global/report/183/flaviviridae |
| Virus Host DB link |
| Paper Title | Proteomic analyses identify intracellular targets for Japanese encephalitis virus nonstructural protein 1 (NS1) |
| Author's Name | Peng Wang 1, Xinze Liu 1, Qi Li 1, Jue Wang 1, Wenke Ruan 6 |
| Journal Name | Virus Research |
| Pubmed ID | 34175344 |
| Abstract | Japanese encephalitis is a zoonotic disease caused by Japanese encephalitis virus (JEV). JEV nonstructural protein 1 (NS1) is involved in many crucial biological events during viral infection and immune suppression. To investigate the role of JEV NS1 in virus-infected cells, the molecules with which it interacts intracellularly were screened with a pull-down assay and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The interaction between heterogeneous nuclear ribonucleoprotein K (hnRNP K), vimentin and NS1 were verified with coimmunoprecipitation and confocal assays. Our results show that JEV NS1 interacts with vimentin, hnRNP K and colocalizes with cellular vimentin and hnRNP K. Furthermore, our results demonstrate that the expression of vimentin and hnRNP K were up-regulated in both NS1-transfected and JEV-infected cells. Knocking down vimentin and hnRNP K reduced viral replication while conversely, over-expression of vimentin and hnRNP K improved viral replication, suggesting an important role for this protein in the viral life cycle. Also, We found that vimentin also interacted with hnRNP K after overexpression of NS1 or JEV infection. These findings provide insight into the molecular mechanism of JEV replication and highlight the key role the NS1 in JEV infection. |
| Used Model | Bhk 21 and pk19 |
| DOI | 10.1016/j.virusres.2021.198499 |
