| Gene Name | LSR |
| HF Protein Name | Lipolysis-Stimulated Lipoprotein Receptor |
| HF Function | |
| Uniprot ID | Q86X29 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 51599 |
| Host Factor (HF) Name in Paper | LSR |
| Gene synonyms | ILDR3 LISCH |
| Ensemble Gene ID | ENSG00000105699 |
| Ensemble Transcript | ENST00000347609.8 [Q86X29-2];ENST00000427250.5 [Q86X29-6];ENST00000621372.4 [Q86X29-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001889, GO:0005886, GO:0005923, GO:0010669, GO:0030054, GO:0034361, GO:0034362, GO:0035633, GO:0042627, GO:0060856, GO:0061436, GO:0061689, GO:0061833, GO:0070062, GO:0070160, GO:1904274, |
| MINT ID | Q86X29 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 616582 |
| PANTHER ID | PTHR15923:SF1;PTHR15923 |
| PDB ID(s) | N.A., |
| pfam ID | PF05624, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Severe Acute Respiratory Syndrome Coronavirus 2 |
| Virus Short Name | SARS CoV-2 |
| Order | Nidovirales |
| Virus Family | Coronaviridae |
| Virus Subfamily | Coronavirinae |
| Genus | Betacoronavirus |
| Species | Betacoronavirus-1 |
| Host | Vertebrates |
| Cell Tropism | Epithelial cells of respiratory or enteric tracts, neurological tissues are also frequently infected |
| Associated Disease | Mainly respiratory diseases |
| Mode of Transmission | Sexual contact, blood, breast feeding |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_search.do?species=Betacoronavirus |
| ICTV DB link | https://ictv.global/report/182/orthocoronavirinae |
| Virus Host DB link |
| Paper Title | Tight junction protein LSR is a host defense factor against SARS-CoV-2 infection in the small intestine |
| Author's Name | Yanan An, Chao Wang, Ziqi Wang, Feng Kong, Hao Liu, Min Jiang, Ti Liu, Shu Zhang, Kaige Du, Liang Yin, Peng Jiao, Ying Li, Baozhen Fan, Chengjun Zhou, Mingxia Wang, Hui Sun, Jie Lei, Shengtian Zhao, Yongfeng Gong. |
| Journal Name | The EMBO Journal |
| Pubmed ID | 39443717 |
| Abstract | The identification of host factors with antiviral potential is important for developing effective prevention and therapeutic strategies against SARS-CoV-2 infection. Here, by using immortalized cell lines, intestinal organoids, ex vivo intestinal tissues and humanized ACE2 mouse model as proof-of-principle systems, we have identified lipolysis-stimulated lipoprotein receptor (LSR) as a crucial host defense factor against SARS-CoV-2 infection in the small intestine. Loss of endogenous LSR enhances ACE2-dependent infection by SARS-CoV-2 Spike (S) protein-pseudotyped virus and authentic SARS-CoV-2 virus, and exogenous administration of LSR protects against viral infection. Mechanistically, LSR interacts with ACE2 both in cis and in trans, preventing its binding to S protein, and thus inhibiting viral entry and S protein-mediated cell-cell fusion. Finally, a small LSR-derived peptide blocks S protein binding to the ACE2 receptor in vitro. These results identify both a previously unknown function for LSR in antiviral host defense against SARS-CoV-2, with potential implications for peptide-based pan-variant therapeutic interventions. |
| Used Model | N/A. |
| DOI | 10.1038/s44318-024-00281-4 |
