Download Help

Virus Details


VHFID10386

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name CD55
HF Protein Name Decay-Accelerating Factor
HF Function
Uniprot ID P08174
Protein Sequence View Fasta Sequence
NCBI Gene ID 1604
Host Factor (HF) Name in Paper CD55
Gene synonyms CR DAF
Ensemble Gene ID ENSG00000196352
Ensemble Transcript ENST00000314754.12 [P08174-2];ENST00000367064.9 [P08174-1];ENST00000644836.1 [P08174-3];ENST00000645323.1 [P08174-5]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000139, GO:0001618, GO:0002726, GO:0005576, GO:0005886, GO:0006958, GO:0007204, GO:0008289, GO:0009986, GO:0030133, GO:0030449, GO:0030667, GO:0031664, GO:0033116, GO:0045087, GO:0045121, GO:0045730, GO:0045916, GO:0070062, GO:0098552, GO:0101003, GO:1903659, GO:2000516, GO:2000563,
MINT ID P08174
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 125240;226300;613793
PANTHER ID PTHR19325;PTHR19325:SF317
PDB ID(s) 1H03, 1H04, 1H2P, 1H2Q, 1M11, 1NWV, 1OJV, 1OJW, 1OJY, 1OK1, 1OK2, 1OK3, 1OK9, 1UOT, 1UPN, 2C8I, 2QZD, 2QZF, 2QZH, 3IYP, 3J24, 5FOA, 6ILJ, 6ILK, 6LA5, 7C9W, 7DO4, 7VY5, 7VY6, 8B8R, 8K9R, 8K9T,
pfam ID PF00084,
Drug Bank ID DB00446,
ChEMBL ID CHEMBL4879428
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Severe Acute Respiratory Syndrome Coronavirus 2
Virus Short Name SARS CoV-2
Order Nidovirales
Virus Family Coronaviridae
Virus Subfamily Coronavirinae
Genus Betacoronavirus
Species Betacoronavirus-1
Host Vertebrates
Cell Tropism Epithelial cells of respiratory or enteric tracts, neurological tissues are also frequently infected
Associated Disease Mainly respiratory diseases
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link https://www.viprbrc.org/brc/vipr_search.do?species=Betacoronavirus
ICTV DB link https://ictv.global/report/182/orthocoronavirinae
Virus Host DB link

Publication Information

Paper Title SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis
Author's Name Laura Gebetsberger, Zahra Malekshahi, Aron Teutsch, Gabor Tajti, Frédéric Fontaine, Nara Marella, André Mueller, Lena Prantl, Hannes Stockinger, Heribert Stoiber, Anna Ohradanova-Repic
Journal Name Emerging Microbes & Infections
Pubmed ID 39435487
Abstract The complement system is a vital anti-microbial defence mechanism against circulating pathogens. Excessive complement activation can have deleterious outcomes for the host and is consequently tightly modulated by a set of membrane-associated and fluid-phase regulators of complement activation (RCAs). Here, we demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks host cellular RCA members CD55 and CD59 and serum-derived Factor H (FH) to resist antibody-dependent complement-mediated lysis triggered by immunized human sera. Blockage of the biological functions of virion-associated CD55 and CD59 and competition of FH recruitment with functionally inactive recombinant FH-derived short consensus repeats SCR18-20 restore SARS-CoV-2 complement sensitivity in a synergistic manner. Moreover, complement-mediated virolysis is dependent on classical pathway activation and does not occur in the absence of virus-specific antibodies. Altogether, our findings present an intriguing immune escape mechanism that provides novel insights into the immunopathology observed in severe coronavirus disease 2019 (COVID-19)
Used Model N/A.
DOI 10.1080/22221751.2024.2417868