| Gene Name | Rrm2 |
| HF Protein Name | Ribonucleotide reductase M2 subunit |
| HF Function | |
| Uniprot ID | P31350 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 6241 |
| Host Factor (HF) Name in Paper | Rrm2 |
| Gene synonyms | RR2 |
| Ensemble Gene ID | ENSG00000171848 |
| Ensemble Transcript | ENST00000304567.10 [P31350-1];ENST00000360566.6 [P31350-2];ENST00000641198.1 [P31350-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001824, GO:0004748, GO:0005634, GO:0005829, GO:0005971, GO:0008199, GO:0009185, GO:0009263, GO:0009265, GO:0042803, GO:0051290, GO:1900087, |
| MINT ID | P31350 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 180390 |
| PANTHER ID | PTHR23409;PTHR23409:SF20 |
| PDB ID(s) | 2UW2, 3OLJ, 3VPM, 3VPN, 3VPO, |
| pfam ID | PF00268, |
| Drug Bank ID | DB00242, DB05260, DB05801, DB05003, DB05428, |
| ChEMBL ID | CHEMBL1954 |
| Organism | Homo sapiens (Human) |
| Virus Name | Severe Acute Respiratory Syndrome Coronavirus 2 |
| Virus Short Name | SARS CoV-2 |
| Order | Nidovirales |
| Virus Family | Coronaviridae |
| Virus Subfamily | Coronavirinae |
| Genus | Betacoronavirus |
| Species | Betacoronavirus-1 |
| Host | Vertebrates |
| Cell Tropism | Epithelial cells of respiratory or enteric tracts, neurological tissues are also frequently infected |
| Associated Disease | Mainly respiratory diseases |
| Mode of Transmission | Sexual contact, blood, breast feeding |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_search.do?species=Betacoronavirus |
| ICTV DB link | https://ictv.global/report/182/orthocoronavirinae |
| Virus Host DB link |
| Paper Title | Novel Core Gene Signature Associated with Inflammation-to-Metaplasia Transition in Influenza A Virus-Infected Lungs |
| Author's Name | Innokenty A Savin, Aleksandra V Sen'kova, Elena P Goncharova, Marina A Zenkova, Andrey V Markov |
| Journal Name | International Journal of Molecular Sciences |
| Pubmed ID | 39596028 |
| Abstract | Respiratory infections caused by RNA viruses are a major contributor to respiratory disease due to their ability to cause annual epidemics with profound public health implications. Influenza A virus (IAV) infection can affect a variety of host signaling pathways that initiate tissue regeneration with hyperplastic and/or dysplastic changes in the lungs. Although these changes are involved in lung recovery after IAV infection, in some cases, they can lead to serious respiratory failure. Despite being ubiquitously observed, there are limited data on the regulation of long-term recovery from IAV infection leading to normal or dysplastic repair represented by inflammation-to-metaplasia transition in mice or humans. To address this knowledge gap, we used integrative bioinformatics analysis with further verification in vivo to elucidate the dynamic molecular changes in IAV-infected murine lung tissue and identified the core genes (Birc5, Cdca3, Plk1, Tpx2, Prc1. Rrm2, Nusap1, Spag5, Top2a, Mcm5) and transcription factors (E2F1, E2F4, NF-YA, NF-YB, NF-YC) involved in persistent lung injury and regeneration processes, which may serve as gene signatures reflecting the long-term effects of IAV proliferation on the lung. Further analysis of the identified core genes revealed their involvement not only in IAV infection but also in COVID-19 and lung neoplasm development, suggesting their potential role as biomarkers of severe lung disease and its complications represented by abnormal epithelial proliferation and oncotransformation. |
| Used Model | N/A. |
| DOI | 10.3390/ijms252211958 |
