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Virus Details


VHFID10413

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name BCL2L1
HF Protein Name BCL2 Like 1
HF Function
Uniprot ID Q07817
Protein Sequence View Fasta Sequence
NCBI Gene ID 598
Host Factor (HF) Name in Paper BCL2L1
Gene synonyms BCL2L BCLX
Ensemble Gene ID ENSG00000171552
Ensemble Transcript ENST00000307677.5 [Q07817-1];ENST00000376055.9 [Q07817-2];ENST00000376062.6 [Q07817-1];ENST00000420488.6 [Q07817-1];ENST00000422920.2 [Q07817-2];ENST00000434194.2 [Q07817-1];ENST00000439267.2 [Q07817-1];ENST00000456404.6 [Q07817-1];ENST00000676582.1 [Q07817-1];ENST00000676942.1 [Q07817-1];ENST00000677194.1 [Q07817-1];ENST00000678563.1 [Q07817-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001541, GO:0001701, GO:0001836, GO:0005737, GO:0005739, GO:0005741, GO:0005743, GO:0005759, GO:0005783, GO:0005813, GO:0005829, GO:0006897, GO:0007281, GO:0007283, GO:0008584, GO:0008630, GO:0008637, GO:0009566, GO:0010507, GO:0015267, GO:0019901, GO:0030672, GO:0031965, GO:0032465, GO:0032946, GO:0034097, GO:0035234, GO:0040008, GO:0042802, GO:0043065, GO:0043066, GO:0043524, GO:0044565, GO:0046898, GO:0046902, GO:0050673, GO:0051093, GO:0051402, GO:0051434, GO:0051607, GO:0051881, GO:0071230, GO:0071312, GO:0071480, GO:0071839, GO:0090201, GO:0097048, GO:0097136, GO:0097192, GO:0097284, GO:1900118, GO:1901029, GO:1902042, GO:1902230, GO:1902236, GO:1903077, GO:2000242, GO:2000669, GO:2000811, GO:2001240, GO:2001243,
MINT ID Q07817
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 600039
PANTHER ID PTHR11256;PTHR11256:SF12
PDB ID(s) 1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4CIN, 4EHR, 4HNJ, 4IEH, 4PPI, 4QVE, 4QVF, 4QVX, 4TUH, 4Z9V, 5AGW, 5AGX, 5B1Z, 5C3G, 5FMJ, 5FMK, 5VAY, 5VX3, 6BF2, 6DCN, 6DCO, 6F46, 6HJL, 6IJQ, 6LHD, 6O0K, 6O0L, 6O0M, 6O0O, 6O0P, 6RNU, 6ST2, 6UVC, 6UVD, 6UVE, 6UVF, 6UVG, 6UVH, 6VWC, 6X7I, 6YLI, 6ZHC, 7CA4, 7JGV, 7JGW, 7LH7, 7XGF, 7XGG, 7Y8D, 7YAA, 8FY0, 8IQK, 8IQL, 8U27, 8VWX, 8VWZ, 8VXM, 8VXN, 8WLS, 8XP5, 9AQZ,
pfam ID PF00452, PF02180,
Drug Bank ID DB07108, DB13044,
ChEMBL ID CHEMBL4625
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Severe Acute Respiratory Syndrome Coronavirus 2
Virus Short Name SARS CoV-2
Order Nidovirales
Virus Family Coronaviridae
Virus Subfamily Coronavirinae
Genus Betacoronavirus
Species Betacoronavirus-1
Host Vertebrates
Cell Tropism Epithelial cells of respiratory or enteric tracts, neurological tissues are also frequently infected
Associated Disease Mainly respiratory diseases
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link https://www.viprbrc.org/brc/vipr_search.do?species=Betacoronavirus
ICTV DB link https://ictv.global/report/182/orthocoronavirinae
Virus Host DB link

Publication Information

Paper Title Investigating SARS-CoV-2 virus-host interactions and mRNA expression: Insights using three models of D. melanogaster
Author's Name Tâmie Duarte, Folorunsho Bright Omage, Guilherme Schmitt Rieder, João B T Rocha, Cristiane Lenz Dalla Corte
Journal Name ELSEVIER
Pubmed ID 38925484
Abstract Responsible for COVID-19, SARS-CoV-2 is a coronavirus in which contagious variants continue to appear. Therefore, some population groups have demonstrated greater susceptibility to contagion and disease progression. For these reasons, several researchers have been studying the SARS-CoV-2/human interactome to understand the pathophysiology of COVID-19 and develop new pharmacological strategies. D. melanogaster is a versatile animal model with approximately 90 % human protein orthology related to SARS-CoV-2/human interactome and is widely used in metabolic studies. In this context, our work assessed the potential interaction between human proteins (ZNF10, NUP88, BCL2L1, UBC9, and RBX1) and their orthologous proteins in D. melanogaster (gl, Nup88, Buffy, ubc9, and Rbx1a) with proteins from SARS-CoV-2 (nsp3, nsp9, E, ORF7a, N, and ORF10) using computational approaches. Our results demonstrated that all the proteins have the potential to interact, and we compared the binding sites between humans and fruit flies. The stability and consistency in the structure of the gl_nsp3 complex, specifically, could be crucial for its specific biological functions. Lastly, to enhance the understanding of the influence of host factors on coronavirus infection, we also analyse the mRNA expression of the five genes (mbo, gl, lwr, Buffy, and Roc1a) responsible for encoding the fruit fly proteins. Briefly, we demonstrated that those genes were differentially regulated according to diets, sex, and age. Two groups showed higher positive gene regulation than others: females in the HSD group and males in the aging group, which could imply a higher virus-host susceptibility. Overall, while preliminary, our work contributes to the understanding of host defense mechanisms and potentially identifies candidate proteins and genes for in vivo viral studies against SARS-CoV-2.
Used Model N/A.
DOI 10.1016/j.bbadis.2024.167324