| Gene Name | HNRNPK |
| HF Protein Name | Heterogeneous Nuclear Ribonucleoprotein K |
| HF Function | Essential for virus replication |
| Uniprot ID | P61978 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3190 |
| Host Factor (HF) Name in Paper | HNRNPK |
| Gene synonyms | HNRPK |
| Ensemble Gene ID | ENSG00000165119 |
| Ensemble Transcript | ENST00000351839.7 [P61978-1];ENST00000360384.9 [P61978-1];ENST00000376263.8 [P61978-2];ENST00000376281.8 [P61978-2];ENST00000457156.6 [P61978-3];ENST00000704004.1 [P61978-3];ENST00000704005.1 [P61978-2];ENST00000704006.1 [P61978-1];ENST00000704011.1 [P61978-2];ENST00000704051.1 [P61978-1];ENST00000704052.1 [P61978-1];ENST00000704053.1 [P61978-1];ENST00000704057.1 [P61978-2];ENST00000704058.1 [P61978-1];ENST00000704059.1 [P61978-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000398, GO:0000785, GO:0002102, GO:0003677, GO:0003723, GO:0003729, GO:0005634, GO:0005654, GO:0005737, GO:0005925, GO:0006357, GO:0006396, GO:0007165, GO:0010494, GO:0010988, GO:0016020, GO:0019904, GO:0031048, GO:0042802, GO:0042995, GO:0043066, GO:0045296, GO:0045892, GO:0045944, GO:0048024, GO:0048025, GO:0048260, GO:0060816, GO:0070062, GO:0071013, GO:1902165, GO:1905599, GO:1990904, |
| MINT ID | P61978 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 600712;616580 |
| PANTHER ID | PTHR10288 |
| PDB ID(s) | 1J5K, 1KHM, 1ZZI, 1ZZJ, 1ZZK, 7CRE, 7CRU, 7RJK, 7RJO, |
| pfam ID | PF00013, PF08067, |
| Drug Bank ID | DB11638, DB12695, |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Nipah virus |
| Virus Short Name | NiV |
| Order | Mononegavirales |
| Virus Family | Paramyxoviridae |
| Virus Subfamily | N.A. |
| Genus | Henipavirus |
| Species | Nipah henipavirus |
| Host | Vertebrates |
| Cell Tropism | N.A. |
| Associated Disease | Fever and headache |
| Mode of Transmission | Sexual contact, blood, breast feeding |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_search.do?species=Nipah_virus |
| ICTV DB link | https://ictv.global/report/152/paramyxoviridae |
| Virus Host DB link |
| Paper Title | Analysis of Nipah Virus Replication and Host Proteome Response Patterns in Differentiated Porcine Airway Epithelial Cells Cultured at the Air-Liquid Interface |
| Author's Name | Martin Müller 1, Kerstin Fischer 2, Elisabeth Woehnke 1, Luca M Zaeck 1, Christoph Prönnecke 3, Michael R Knittler 4, Axel Karger 1, Sandra Diederich 2, Stefan Finke 18 |
| Journal Name | Viruses |
| Pubmed ID | 37112941 |
| Abstract | Respiratory tract epithelium infection plays a primary role in Nipah virus (NiV) pathogenesis and transmission. Knowledge about infection dynamics and host responses to NiV infection in respiratory tract epithelia is scarce. Studies in non-differentiated primary respiratory tract cells or cell lines indicate insufficient interferon (IFN) responses. However, studies are lacking in the determination of complex host response patterns in differentiated respiratory tract epithelia for the understanding of NiV replication and spread in swine. Here we characterized infection and spread of NiV in differentiated primary porcine bronchial epithelial cells (PBEC) cultivated at the air-liquid interface (ALI). After the initial infection of only a few apical cells, lateral spread for 12 days with epithelium disruption was observed without releasing substantial amounts of infectious virus from the apical or basal sides. Deep time course proteomics revealed pronounced upregulation of genes related to type I/II IFN, immunoproteasomal subunits, transporter associated with antigen processing (TAP)-mediated peptide transport, and major histocompatibility complex (MHC) I antigen presentation. Spliceosomal factors were downregulated. We propose a model in which NiV replication in PBEC is slowed by a potent and broad type I/II IFN host response with conversion from 26S proteasomes to immunoproteasomal antigen processing and improved MHC I presentation for adaptive immunity priming. NiV induced cytopathic effects could reflect the focal release of cell-associated NiV, which may contribute to efficient airborne viral spread between pigs. |
| Used Model | PBEC-ALI |
| DOI | 10.3390/v15040961 |
