| Gene Name | IFITM3 |
| HF Protein Name | Interferon-induced transmembrane protein 3 |
| HF Function | Essential for virus infection |
| Uniprot ID | Q01628 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 10410 |
| Host Factor (HF) Name in Paper | IFITM3 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000142089 |
| Ensemble Transcript | ENST00000399808 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005765, GO:0005886, GO:0006955, GO:0009615, GO:0016021, GO:0031902, GO:0032897, GO:0034341, GO:0035455, GO:0035456, GO:0045071, GO:0046597, GO:0051607, GO:0060337, GO:0070062, |
| MINT ID | Q01628 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605579 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF04505, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human coronavirus 229E |
| Virus Short Name | HCoV-229E |
| Order | Nidovirales |
| Virus Family | Coronaviridae |
| Virus Subfamily | Coronavirinae |
| Genus | Alphacoronavirus |
| Species | Alphacoronavirus 1 |
| Host | Human, pig, cat, dog and bat |
| Cell Tropism | Epithelial cells of respiratory or enteric tracts, neurological tissues are also frequently infected |
| Associated Disease | Mainly respiratory diseases, and gastroenteritis |
| Mode of Transmission | Respiratory or fecal-oral in humans |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=corona |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/222/coronaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Coronaviridae |
| Paper Title | Interferon induction of IFITM proteins promotes infection by human coronavirus OC43 |
| Author's Name | Xuesen Zhao, Fang Guo, Fei Liu, Andrea Cuconati, Jinhong Chang, Timothy M. Block, and Ju-Tao Guo |
| Journal Name | PLOS Pathogens |
| Pubmed ID | 24753610 |
| Abstract | IFNs are a family of cytokines that are essential for the antiviral response in vertebrates. Not surprisingly, viruses have adapted to encode virulence factors to cope with the IFN response. Intriguingly, we show here that all three types of interferons, IFN-alpha, IFN-gamma, and IFN-lambda, efficiently promote infection by a human coronavirus, HCoV-OC43, one of the major etiological agents of common cold, through the induction of IFN-inducible transmembrane (IFITM) proteins. IFITMs typically exert their antiviral function by inhibiting the entry of a broad spectrum of viruses into their host cells, presumably by trapping and degrading invading virions within the endocytic compartments. In contrast, HCoV-OC43 uses IFN-induced human IFITM2 or IFITM3 as an entry factor to facilitate its infection of host cells. Reverse genetics analyses suggest that the structural motifs critical for the IFITM proteins enhancement of HCoV-OC43 infection are distinct from those required for inhibiting infection by other viruses. We also present evidence showing that IFITM family members work as homo- and hetero-oligomers to modulate virus entry. The observed enhancement of HCoV-OC43 infection by IFNs may underlie the propensity of the virus to invade the lower respiratory tract under inflammatory conditions. |
| Used Model | Huh7.5 and NCI-H520-derived stable cell lines |
| DOI | 10.1073/pnas.1320856111 |
