| Gene Name | tvb |
| HF Protein Name | TvbS1 |
| HF Function | Essential for viral entry |
| Uniprot ID | Q9IAR7 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 373904 |
| Host Factor (HF) Name in Paper | TVB |
| Gene synonyms | TNFRSF10B |
| Ensemble Gene ID | ENSGALG00000000452 |
| Ensemble Transcript | ENSGALT00000040952 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005031, GO:0005887, GO:0006954, GO:0006955, GO:0007275, GO:0032496, GO:0042127, GO:0042981, GO:0045569, GO:0097190, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF00531, PF00020, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Gallus gallus (Chicken) |
| Virus Name | Avian leukosis virus |
| Virus Short Name | ALV |
| Order | Unassigned |
| Virus Family | Retroviridae |
| Virus Subfamily | Orthoretrovirinae |
| Genus | Alpharetrovirus |
| Species | Avian leukosis virus |
| Host | Vertebrates |
| Cell Tropism | N.A. |
| Associated Disease | Malignancies |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae |
| Paper Title | Amino acid residues Tyr-67, Asn-72, and Asp-73 of the TVB receptor are important for subgroup E avian sarcoma and leukosis virus interaction |
| Author's Name | Sara Klucking and John A.T. Young |
| Journal Name | Virology |
| Pubmed ID | 14972562 |
| Abstract | The chicken TVB(S1) protein serves as the cellular receptor for the cytopathic subgroups B and D avian sarcoma and leukosis viruses (ASLVs) as well as for the non-cytopathic subgroup E ASLV. Previous studies had mapped the subgroup B viral interaction determinants to a region that was located between residues 32 and 46 of TVB(S1) [J. Virol. 76 (2002) 5404]. To gain a greater insight into ASLV Env-receptor interactions and the possible role of these interactions in viral cytopathic effects, we employed a homolog-scanning mutagenesis approach to identify amino acid residues important for subgroup E viral receptor function by exchanging amino acid residues between TVB(S1) and its human homolog, DR5. These studies identified residues Tyr-67, Asn-72, and Asp-73 of TVB(S1) as important subgroup E viral interaction determinants. Intriguingly, these three residues are conserved between TVB(S1) and DR5, demonstrating that the human protein contains critical subgroup E viral interaction determinants, but in this context, they cannot support viral entry. These data confirm that the molecular determinants of the TVB receptor required for subgroup E viral entry are completely distinct from those used by subgroup B viruses. |
| Used Model | HEK 293 cells |
| DOI | 10.1016/j.virol.2003.09.024 |
