| Gene Name | ZC3HAV1 |
| HF Protein Name | Zinc finger CCCH-type containing, antiviral 1 |
| HF Function | Inhibits avian tumor virus replication |
| Uniprot ID | F1NWL9 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | N.A. |
| Host Factor (HF) Name in Paper | ZAP |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSGALG00000013911 |
| Ensemble Transcript | ENSGALT00000022552 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0003950, GO:0046872, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF00644, PF02825, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Gallus gallus (Chicken) |
| Virus Name | Avian leukosis virus |
| Virus Short Name | ALV |
| Order | Unassigned |
| Virus Family | Retroviridae |
| Virus Subfamily | Orthoretrovirinae |
| Genus | Alpharetrovirus |
| Species | Avian leukosis virus |
| Host | Vertebrates |
| Cell Tropism | N.A. |
| Associated Disease | Malignancies |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae |
| Paper Title | Inhibition of avian tumor virus replication by CCCH-type zinc nger antiviral protein |
| Author's Name | Mingjun Zhu, Xiaoqian Ma, Xiyao Cui, Jing Zhou, Chengui Li, Libo Huang, Yingli Shang and Ziqiang Cheng |
| Journal Name | Oncotarget |
| Pubmed ID | 28938603 |
| Abstract | CCCH type zinc finger antiviral protein (ZAP) is a host restriction factor that inhibits the replication of a variety of viruses in mammals. However, little is known about its antiviral activity on avian tumor virus. Avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, induces myelocytomas and various other tumors in meat and egg type chickens. Here, we identified a chicken ZAP (chZAP) that increased at early stage, and subsequently decreased after infection of ALV-J in DF-1 cells, indicating the inducible feature of the endogenous chZAP. To demonstrate the inhibitory effect on ALV-J replication by chZAP, we expressed exogenous chZAP by lentivirus based vectors in DF-1 cells that infected by ALV-J. The result showed that overexpression of chZAP significantly inhibited ALV-J replication at both mRNA level and protein level. Consequently, knockdown of endogenous chZAP by RNAi facilitated ALV-J replication in DF-1 cells. Further, we demonstrated that chZAP interacts with SU protein (encode by gp85 gene) of ALV-J in cytoplasm. Taken together, our results demonstrated that chZAP inhibits ALV-J by both mRNA and protein pathway and it may shed light on a novel antiviral approach in poultry. |
| Used Model | DF-1 and 293T cells |
| DOI | 10.18632/oncotarget.19378 |
