Download Help

Virus Details


VHFID1505

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name ACE2
HF Protein Name Angiotensin-converting enzyme 2
HF Function Functional receptor for the SARS Corona virus
Uniprot ID Q9BYF1
Protein Sequence View Fasta Sequence
NCBI Gene ID 59272
Host Factor (HF) Name in Paper ACE2
Gene synonyms N.A.
Ensemble Gene ID ENSG00000130234
Ensemble Transcript ENST00000252519 [Q9BYF1-1];ENST00000427411 [Q9BYF1-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001618, GO:0001817, GO:0002003, GO:0002005, GO:0003051, GO:0003081, GO:0004175, GO:0004180, GO:0004181, GO:0005576, GO:0005615, GO:0005737, GO:0005886, GO:0008270, GO:0009986, GO:0015827, GO:0016021, GO:0019229, GO:0032800, GO:0042127, GO:0045121, GO:0046718, GO:0046813, GO:0050727, GO:0060452, GO:0070062, GO:0097746, GO:1903598, GO:1903779, GO:2000379,
MINT ID Q9BYF1
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 300335
PANTHER ID PTHR10514
PDB ID(s) 1R42, 1R4L, 1XJP, 2AJF, 3D0G, 3D0H, 3D0I, 3KBH, 3SCI, 3SCJ, 3SCK, 3SCL,
pfam ID PF16959, PF01401,
Drug Bank ID DB00722, DB00691, DB05203, DB05358,
ChEMBL ID CHEMBL3736
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human SARS coronavirus
Virus Short Name SARS-CoV
Order Nidovirales
Virus Family Coronaviridae
Virus Subfamily Coronavirinae
Genus Betacoronavirus
Species Betacoronavirus 1
Host Bats, human
Cell Tropism Epithelial cells of respiratory or enteric tracts, neurological tissues are also frequently infected
Associated Disease Mainly respiratory diseases
Mode of Transmission Respiratory or fecal-oral in humans
VIPR DB link https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=corona
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/222/coronaviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Coronaviridae

Publication Information

Paper Title Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Author's Name Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M.
Journal Name NATURE
Pubmed ID 14647384
Abstract Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target cells. Here we identify a metallopeptidase, angiotensin-converting enzyme 2(ACE2), isolated from SARS coronavirus (SARS-CoV)-permissive Vero E6 cells, that efficiently binds the S1 domain of the SARS-CoV S protein. We found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells. 293T cells transfected with ACE2, but not those transfected with human immunodeficiency virus-1 receptors, formed multinucleated syncytia with cells expressing S protein. Furthermore, SARS-CoV replicated efficiently on ACE2-transfected but not mock-transfected 293T cells. Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together our data indicate that ACE2 is a functional receptor for SARS-CoV.
Used Model Vero E6 and 293T cells
DOI 10.1038/nature02145