| Gene Name | HNRNPK |
| HF Protein Name | Heterogeneous nuclear ribonucleoprotein K |
| HF Function | Required for Dengue Virus multiplication |
| Uniprot ID | P61978 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3190 |
| Host Factor (HF) Name in Paper | HNRNPK |
| Gene synonyms | HNRPK |
| Ensemble Gene ID | ENSG00000165119 |
| Ensemble Transcript | ENST00000351839 [P61978-1];ENST00000360384 [P61978-1];ENST00000376263 [P61978-2];ENST00000376281 [P61978-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000398, GO:0000790, GO:0000978, GO:0001077, GO:0002102, GO:0003697, GO:0003723, GO:0005634, GO:0005654, GO:0005737, GO:0005925, GO:0006396, GO:0007165, GO:0010988, GO:0016020, GO:0016032, GO:0016070, GO:0019904, GO:0042802, GO:0042995, GO:0043066, GO:0045296, GO:0045716, GO:0045944, GO:0048025, GO:0048260, GO:0070062, GO:0071013, GO:0072369, GO:1902165, |
| MINT ID | P61978 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 600712 |
| PANTHER ID | PTHR10288:SF221 |
| PDB ID(s) | 1J5K, 1KHM, 1ZZI, 1ZZJ, 1ZZK, |
| pfam ID | PF00013, PF08067, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Dengue virus 2 |
| Virus Short Name | DENV 2 |
| Order | Unassigned |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Dengue virus |
| Host | Human, mammals, mosquitoes and ticks |
| Cell Tropism | Phagocytes, hepatocytes |
| Associated Disease | Dengue fever |
| Mode of Transmission | Arthropod bite, mainly mosquitoes |
| VIPR DB link | http://www.viprbrc.org/brc/home.spg?decorator=flavi |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae |
| Paper Title | The�heterogeneous�nuclear�ribonucleoprotein�K�(hnRNP�K) is a�host�factor�required�for�denguevirus�and Jun�n�virus�multiplication |
| Author's Name | Brunetti JE,�Scolaro LA,�Castilla V |
| Journal Name | Virus Research |
| Pubmed ID | 25865411 |
| Abstract | Heterogeneous nuclear ribonucleoproteins (hnRNPs) are cellular factors involved in the replication of several viruses. In this study we analyzed the expression and intracellular localization of hnRNP A2 and hnRNP K in cell cultures infected with two viruses that cause human hemorrhagic fevers: dengue virus type 2 (DENV-2) and JunÃn virus (JUNV). We determined that DENV-2 promoted the cytoplasmic translocation of hnRNP K and to a lesser extent of hnRNP A2, meanwhile, JUNV infection induced an increase in hnRNP Kcytoplasmic localization whereas hnRNP A2 remained mainly in the nucleus of infected cells. Both hnRNP K and hnRNP A2 were localized predominantly in the nucleus of JUNV persistently-infected cells even after superinfection with JUNV indicating that persistent infection does not alter nucleo-cytoplasmic transport of these hnRNPs. Total levels of hnRNP K expression were unaffected by DENV-2 or JUNV infection. In addition we determined, using small interfering RNAs, that hnRNP K knockout inhibits DENV-2 and JUNV multiplication. Our results indicate that DENV-2 and JUNV induce hnRNP K cytoplasmic translocation to favor viral multiplication. |
| Used Model | A549 cells |
| DOI | 10.1016/j.virusres.2015.04.001 |
