| Gene Name | ICAM5 |
| HF Protein Name | Intercellular adhesion molecule 5 |
| HF Function | Entry Receptor for Enterovirus D68 |
| Uniprot ID | Q9UMF0 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 7087 |
| Host Factor (HF) Name in Paper | ICAM5 |
| Gene synonyms | TLCN TLN |
| Ensemble Gene ID | ENSG00000105376 |
| Ensemble Transcript | ENST00000221980 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005178, GO:0005886, GO:0005887, GO:0006909, GO:0007155, GO:0030198, GO:0050776, GO:0098609, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 601852 |
| PANTHER ID | N.A. |
| PDB ID(s) | 3BN3, 4OI9, 4OIA, 4OIB, |
| pfam ID | PF03921, PF13895, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Enterovirus D68 |
| Virus Short Name | EV-D68 |
| Order | Picornavirales |
| Virus Family | Picornaviridae |
| Virus Subfamily | N.A. |
| Genus | Enterovirus |
| Species | Enterovirus D |
| Host | Human, mammals |
| Cell Tropism | Upper respiratory tract |
| Associated Disease | Respiratory disease |
| Mode of Transmission | Feces,saliva, nasal mucus, or sputum |
| VIPR DB link | https://www.viprbrc.org/brc/home.spg?decorator=picorna |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/234/picornaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Picornaviridae |
| Paper Title | ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68 |
| Author's Name | Wei Wei, Haoran Guo, Junliang Chang, Yingzi Yu, Guanchen Liu, Nannan Zhang, Stephen H. Willard, Shu Zheng, and Xiao-Fang Yu |
| Journal Name | Cell Host & Microbe |
| Pubmed ID | 27923705 |
| Abstract | Enterovirus D68 (EV-D68) is a member of the Picornaviridae family. Although EV-D68-associated infection was once considered rare, it has been increasing in recent years. EV-D68 infection is most frequently associated with respiratory illness. However, it has also been implicated in a polio-like neurological disorder, acute flaccid myelitis. Although sialic acid has been implicated in EV-D68 entry, the existence of a protein receptor has yet to be clarified. Here we identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent EV-D68 viruses. EV-D68 bound specifically and efficiently to ICAM-5, and replication of EV-D68 in diverse cell types was inhibited by soluble ICAM-5 fragments. ICAM-5 silencing attenuated EV-D68 replication in permissive cells, and ICAM-5 expression in non-permissive cells allowed EV-D68 replication. The discovery of a neuron-specific adhesion molecule as an EV-D68 receptor has important implications for EV-D68 pathogenesis and may facilitate the development of novel intervention strategies. |
| Used Model | HEK 293T and RD cells |
| DOI | 10.1016/j.chom.2016.09.013 |
