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Virus Details


VHFID3202

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name TGFB1
HF Protein Name Transforming growth factor beta-1
HF Function Antiviral protein
Uniprot ID P01137
Protein Sequence View Fasta Sequence
NCBI Gene ID 7040
Host Factor (HF) Name in Paper TGFB1
Gene synonyms TGFB
Ensemble Gene ID ENSG00000105329
Ensemble Transcript ENST00000221930
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000060, GO:0000122, GO:0000165, GO:0001570, GO:0001657, GO:0001666, GO:0001837, GO:0001843, GO:0001933, GO:0001934, GO:0002028, GO:0002062, GO:0002244, GO:0002248, GO:0002460, GO:0002513, GO:0002576, GO:0003179, GO:0003823, GO:0005114, GO:0005125, GO:0005160, GO:0005576, GO:0005578, GO:0005615, GO:0005634, GO:0005737, GO:0005796, GO:0005886, GO:0006468, GO:0006611, GO:0006754, GO:0006796, GO:0006874, GO:0006954, GO:0007050, GO:0007093, GO:0007173, GO:0007179, GO:0007182, GO:0007183, GO:0007219, GO:0007406, GO:0007435, GO:0007492, GO:0007507, GO:0007565, GO:0007568, GO:0008083, GO:0008156, GO:0008284, GO:0008285, GO:0008354, GO:0009611, GO:0009749, GO:0009817, GO:0009986, GO:0010575, GO:0010628, GO:0010629, GO:0010716, GO:0010718, GO:0010742, GO:0010763, GO:0010800, GO:0010862, GO:0010936, GO:0014003, GO:0016202, GO:0016477, GO:0017015, GO:0019049, GO:0019221, GO:0019899, GO:0021915, GO:0022408, GO:0030214, GO:0030279, GO:0030308, GO:0030334, GO:0030335, GO:0030424, GO:0030501, GO:0,
MINT ID P01137
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 131300
PANTHER ID PTHR11848
PDB ID(s) 1KLA, 1KLC, 1KLD, 3KFD, 4KV5, 5FFO, 5VQP,
pfam ID PF00019, PF00688,
Drug Bank ID DB00070, DB06205,
ChEMBL ID CHEMBL1795178
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Hepatitis B virus
Virus Short Name HBV
Order Unassigned
Virus Family Hepadnaviridae
Virus Subfamily N.A.
Genus Orthohepadnavirus
Species Hepatitis B virus
Host Human, mammals
Cell Tropism Hepatocytes
Associated Disease Hepatitis,hepatocellular carcinoma(chronic infections),cirrhosis
Mode of Transmission Sexual contact, blood, maternal-neonatal
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae
Virus Host DB link N.A.

Publication Information

Paper Title Differential expression of transforming growth factor�beta1 and HBx enhances hepatitis B virus replication and augments host immune cytokines and chemokines
Author's Name Fahad N, Almajhdi, Ahmed Y. Al-Qudari, Zahid Hussain
Journal Name Annals of Hepatology
Pubmed ID 23619257
Abstract BACKGROUND/AIMS: This study investigated how HBV replication and host immune response are effected by reduced expression of TGF-beta1 and HBx.This study investigated how HBV replication and host immune response are effected by reduced expression of TGF-beta1 and HBx.MATERIAL AND METHODS:Short interfering RNA (siRNA) knockdown technology has been used to examine the role of TGF-beta1 in hepatitis B virus replication. The siTGF-beta1 has been transfected along with 1.3mer HBV x-null to investigate the knockdown effect of TGF-beta1 on HBV replication and host immune factors. RESULTS: In this study, we found that diminished expression of TGF-beta1 and increased expression of HBx enhances HBV replication several folds. The differential expression of TGF-beta1 and HBx also stimulated transcriptional viral replicative intermediate (pgRNA) and secretion of core and e antigen at translational level. Consequently, several cytokines such as IL-2, IL-8 and chemokine monocyte- chemoattractant protein (MCP-1) were increased significantly in response to stimulation of HBV replication. In contrast, TNF-alpha and RANTES mRNA expression increased insignificantly in response to enhanced HBV replication.CONCLUSIONS:We concluded that reduced expression of TGF-beta1 together with HBx expression stimulate HBV replication and immune response, although the underlying mechanism of stimulation most likely differs.
Used Model HepG2 cells
DOI NA