| Gene Name | IL21 |
| HF Protein Name | Interleukin-21 |
| HF Function | Inhibits HBV replication |
| Uniprot ID | Q9HBE4 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 59067 |
| Host Factor (HF) Name in Paper | IL21 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000138684 |
| Ensemble Transcript | ENST00000264497;ENST00000611104 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001819, GO:0005125, GO:0005126, GO:0005134, GO:0005576, GO:0005615, GO:0005622, GO:0006955, GO:0007165, GO:0007260, GO:0008284, GO:0030890, GO:0032740, GO:0034105, GO:0038114, GO:0042102, GO:0042531, GO:0045078, GO:0045954, GO:0048469, GO:0050729, |
| MINT ID | Q9HBE4 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605384 |
| PANTHER ID | PTHR14356 |
| PDB ID(s) | 2OQP, 3TGX, |
| pfam ID | PF02372, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Hepatitis B virus |
| Virus Short Name | HBV |
| Order | Unassigned |
| Virus Family | Hepadnaviridae |
| Virus Subfamily | N.A. |
| Genus | Orthohepadnavirus |
| Species | Hepatitis B virus |
| Host | Human, mammals |
| Cell Tropism | Hepatocytes |
| Associated Disease | Hepatitis, hepatocellular carcinoma(chronic infections), cirrhosis |
| Mode of Transmission | Sexual contact, blood, maternal-neonatal |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae |
| Virus Host DB link | N.A. |
| Paper Title | Interleukin 21 inhibits HBV replication in vitro |
| Author's Name | Hai-Jun Li, Fu-Biao Kang, Bao-Sheng Li, Xin-Ying Yang, Yin-Ge Zhang, Dian-Xing Sun |
| Journal Name | Antiviral Therapy |
| Pubmed ID | 25774942 |
| Abstract | BACKGROUND: Cytokines are crucial factors in the non-cytolytic antiviral process to inhibit HBV gene expression and replication. Interleukin (IL)-21 has been suggested to play an important role in HBV infection, but it remains unknown whether IL-21 can inhibit HBV replication or how it inhibits HBV replication.METHODS: In this study, we investigated the influence of IL-21 on HBV replication based on human hepatoma Huh7.93 cells co-cultured with human peripheral blood mononuclear cells (PBMCs) and the possible correlation among IL-21, interferon-gamma, tumour necrosis factor-alpha and IL-10.RESULTS: We demonstrated that the decrease of IL-21 expression and the increase of IL-10 expression in PBMCs could promote HBV replication in vitro. We further revealed that IL-21 is not only able to effectively suppress HBV replication directly but also reduce HBV replication by inhibition of IL-10 secretion. CONCLUSIONS: Our results provide important evidence for the non-cytolytic antiviral mechanism mediated by cytokines and their interactions in chronic hepatitis B. |
| Used Model | Huh7.93 cells |
| DOI | 10.3851/IMP2950 |
