| Gene Name | ABCC6 |
| HF Protein Name | Multidrug resistance-associated protein 6 |
| HF Function | Sustains chronic virus infection |
| Uniprot ID | O95255 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 368 |
| Host Factor (HF) Name in Paper | URG7 |
| Gene synonyms | ARA MRP6 |
| Ensemble Gene ID | ENSG00000091262 |
| Ensemble Transcript | ENST00000205557 [O95255-1];ENST00000456970 [O95255-3];ENST00000575728 [O95255-2];ENST00000600761 [O95255-2];ENST00000622290 [O95255-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005215, GO:0005524, GO:0005634, GO:0005789, GO:0005886, GO:0007601, GO:0016021, GO:0016323, GO:0016324, GO:0016328, GO:0042493, GO:0042626, GO:0043225, GO:0055085, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 264800 |
| PANTHER ID | PTHR24223:SF339 |
| PDB ID(s) | N.A., |
| pfam ID | PF00664, PF00005, |
| Drug Bank ID | DB00515, DB00970, DB00694, DB00997, DB00773, DB00328, DB01032, DB01138, DB00444, DB00570, |
| ChEMBL ID | CHEMBL2073661 |
| Organism | Homo sapiens (Human) |
| Virus Name | Hepatitis B virus |
| Virus Short Name | HBV |
| Order | Unassigned |
| Virus Family | Hepadnaviridae |
| Virus Subfamily | N.A. |
| Genus | Orthohepadnavirus |
| Species | Hepatitis B virus |
| Host | Human, mammals |
| Cell Tropism | Hepatocytes |
| Associated Disease | Hepatitis, hepatocellular carcinoma(chronic infections), cirrhosis |
| Mode of Transmission | Sexual contact, blood, maternal-neonatal |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae |
| Virus Host DB link | N.A. |
| Paper Title | The hepatitis B x antigen anti-apoptotic effector URG7 is localized to the endoplasmic reticulum membrane |
| Author's Name | A. Ostuni, P. Lara , M.F. Armentano, R. Miglionico, A.M. Salvia, M. Monnich, M. CarmosinoF.M. Lasorsa, M. Monne, I. Nilsson, F. Bisaccia |
| Journal Name | FEBS Letter |
| Pubmed ID | 23912081 |
| Abstract | Hepatitis B x antigen up-regulates the liver expression of URG7 that contributes to sustain chronic virus infection and to increase the risk for hepatocellular carcinoma by its anti-apoptotic activity. We have investigated the subcellular localization of URG7 expressed in HepG2 cells and determined its membrane topology by glycosylation mapping in vitro. The results demonstrate that URG7 is N-glycosylated and located to the endoplasmic reticulum membrane with an Nlumen-Ccytosol orientation. The results imply that the anti-apoptotic effect of URG7 could arise from the C-terminal cytosolic tail binding a pro-apoptotic signaling factor and retaining it to the endoplasmic reticulum membrane. |
| Used Model | HepG2 cells |
| DOI | 10.1016/j.febslet.2013.07.042 |
