| Gene Name | RSAD2 |
| HF Protein Name | Radical S-adenosyl methionine domain-containing protein 2 |
| HF Function | Antiviral protein |
| Uniprot ID | Q8WXG1 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 91543 |
| Host Factor (HF) Name in Paper | Viperin |
| Gene synonyms | CIG5 |
| Ensemble Gene ID | ENSG00000134321 |
| Ensemble Transcript | ENST00000382040 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001650, GO:0003824, GO:0005739, GO:0005741, GO:0005743, GO:0005783, GO:0005789, GO:0005794, GO:0005811, GO:0009615, GO:0016032, GO:0034157, GO:0034165, GO:0035710, GO:0043367, GO:0043621, GO:0045071, GO:0046872, GO:0050709, GO:0051539, GO:0051607, GO:0060337, GO:2000553, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 607810 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF04055, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Herpes Simplex Virus 1 counteracts viperin via Its virion host shutoff protein UL41 |
| Author's Name | Guanghui Shen, Kezhen Wang, Shuai Wang, Mingsheng Cai, Mei-li Li, Chunfu Zheng |
| Journal Name | Journal Of Virology |
| Pubmed ID | 25078699 |
| Abstract | The interferon (IFN)-inducible viperin protein restricts a broad range of viruses. However, whether viperin plays a role during herpes simplex virus 1 (HSV-1) infection is poorly understood. In the present study, it was shown for the first time that wild-type (WT) HSV-1 infection couldnt induce viperin production, and ectopically expressed viperin inhibited the replication of UL41-null HSV-1 but not WT viruses. The underlying molecular mechanism is that UL41 counteracts viperins antiviral activity by reducing its mRNA accumulation. |
| Used Model | HEK293T cells |
| DOI | 10.1128/JVI.01380-14 |
