| Gene Name | TNFRSF14 |
| HF Protein Name | Tumor necrosis factor receptor superfamily member 1 |
| HF Function | Receptor for viral entry |
| Uniprot ID | Q92956 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 8764 |
| Host Factor (HF) Name in Paper | HVEM |
| Gene synonyms | HVEA HVEM |
| Ensemble Gene ID | ENSG00000130202 |
| Ensemble Transcript | ENST00000355716 [Q92956-1];ENST00000621877 [Q92956-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0005031, GO:0005886, GO:0005887, GO:0006954, GO:0006955, GO:0007166, GO:0007275, GO:0031295, GO:0031625, GO:0032496, GO:0033209, GO:0042127, GO:0042981, GO:0097190, |
| MINT ID | Q92956 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 602746 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1JMA, 2AW2, 4FHQ, 4RSU, |
| pfam ID | PF00020, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family |
| Author's Name | Rebecca I. Montgomery, Morgyn S. Warner, Brian J. Lum, and Patricia G. Spear |
| Journal Name | Cell |
| Pubmed ID | 8898196 |
| Abstract | We identified and cloned a cellular mediator of herpes simplex virus (HSV) entry. Hamster and swine cells resistant to viral entry became susceptible upon expression of a human cDNA encoding this protein, designated HVEM (for herpesvirus entry mediator). HVEM was shown to mediate the entry of several wild-type HSV strains of both serotypes. Anti-HVEM antibodies and a soluble hybrid protein containing the HVEM ectodomain inhibited HVEM-dependent infection but not virus binding to cells. Mutations in the HSV envelope glycoprotein gD significantly reduced HVEM-mediated entry. The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells. HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family. |
| Used Model | CHO cells |
| DOI | 10.1016/S0092-8674(00)81363-X |
