| Gene Name | GMNN |
| HF Protein Name | Geminin |
| HF Function | Inhibits MCM loading by Cdt1 |
| Uniprot ID | O75496 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 51053 |
| Host Factor (HF) Name in Paper | Geminin |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000112312 |
| Ensemble Transcript | ENST00000230056;ENST00000356509;ENST00000620958 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0003682, GO:0003714, GO:0005634, GO:0005654, GO:0005737, GO:0005829, GO:0008156, GO:0009887, GO:0035563, GO:0042826, GO:0045786, GO:0045892, GO:0070491, GO:0071163, GO:2000104, |
| MINT ID | O75496 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 602842 |
| PANTHER ID | PTHR13372:SF4 |
| PDB ID(s) | 1T6F, 1UII, 2LP0, 2WVR, 4BRY, |
| pfam ID | PF07412, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL1293278 |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 4 (Epstein-Barr virus) |
| Virus Short Name | EBV |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Gammaherpesvirinae |
| Genus | Lymphocryptovirus |
| Species | Human herpesvirus 4 |
| Host | Vertebrates |
| Cell Tropism | B lymphocytes, oral epithelial cells, latency: remains latent in cd19+ b cells |
| Associated Disease | Mononucleosis, associated with environemental diseases: burkitt’s lymphoma nasopharyngeal carcinoma (npc) |
| Mode of Transmission | Sexual contact, blood, breast feeding |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin |
| Author's Name | Dhar SK, Yoshida K, Machida Y, Khaira P, Chaudhuri B, Wohlschlegel JA, Leffak M, Yates J, Dutta A. |
| Journal Name | cell |
| Pubmed ID | 11509178 |
| Abstract | Epstein-Barr virus episomes (EBV) replicate once per cell cycle during latent infection from the latent origin, oriP. This replication requires the viral EBNA1 protein, which specifically recognizes sequences in oriP and recruits cellular proteins to this origin. Replication from oriP requires the cellular origin recognition and MCM helicase complexes and also involves telomeric factors (including TRF2) that associate with repeated nonameric sequences at the origin. Replication from oriP occurs late in S-phase and this timing appears to be important for efficient replication. Replication from oriP has proven to be a valuable system for elucidating cellular proteins and mechanisms of origin activation. |
| Used Model | B cells |
| DOI | 10.1016/S0092-8674(01)00458-5 |
