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Virus Details


VHFID4084

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name CYP3A4
HF Protein Name Cytochrome P450 3A4
HF Function Essential for viral replication
Uniprot ID P08684
Protein Sequence View Fasta Sequence
NCBI Gene ID 1576
Host Factor (HF) Name in Paper CYP3A4
Gene synonyms CYP3A3
Ensemble Gene ID ENSG00000160868
Ensemble Transcript ENST00000336411
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0002933, GO:0004497, GO:0005496, GO:0005506, GO:0005737, GO:0005789, GO:0006629, GO:0006706, GO:0006805, GO:0008202, GO:0008209, GO:0008395, GO:0009822, GO:0016021, GO:0016098, GO:0016491, GO:0016712, GO:0017144, GO:0019825, GO:0019899, GO:0020037, GO:0030343, GO:0031090, GO:0034875, GO:0042359, GO:0042737, GO:0042738, GO:0043231, GO:0046483, GO:0050649, GO:0055114, GO:0070576, GO:0070989, GO:0101020,
MINT ID N.A.
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 124010
PANTHER ID N.A.
PDB ID(s) 1TQN, 1W0E, 1W0F, 1W0G, 2J0D, 2V0M, 3NXU, 3TJS, 3UA1, 4D6Z, 4D75, 4D78, 4D7D, 4I3Q, 4I4G, 4I4H, 4K9T, 4K9U, 4K9V, 4K9W, 4K9X, 4NY4, 5A1P, 5A1R, 5G5J, 5TE8, 5VC0, 5VCC, 5VCD, 5VCE, 5VCG, 6BCZ, 6BD5, 6BD6, 6BD7, 6BD8, 6BDH, 6BDI, 6BDK, 6BDM,
pfam ID PF00067,
Drug Bank ID DB05812, DB01418, DB00316, DB00819, DB00546, DB00518, DB00240, DB00041, DB00802, DB00346, DB01246, DB09026, DB01431, DB00918, DB06203, DB00969, DB00404, DB06403, DB06742, DB00357, DB01424, DB01223, DB01118, DB00321, DB00381, DB00701, DB01217, DB01435, DB06605, DB05676, DB00673, DB00278, DB01238, DB06413, DB01169, DB06697, DB06216, DB00637, DB01072, DB00289, DB01076, DB06237, DB06626, DB00719, DB00972, DB04957, DB00207, DB04975, DB08903, DB00865, DB06770, DB00443, DB00307, DB01393, DB01128, DB04794, DB00612, DB08873, DB00188, DB00559, DB06616, DB08870, DB09128, DB01194, DB01558, DB01200, DB00835, DB01222, DB00297, DB00921, DB01156, DB00490, DB01008, DB06772, DB00248, DB08875, DB00201, DB04886, DB00136, DB08907, DB06774, DB00564, DB00748, DB06016, DB01136, DB00520, DB01333, DB00482, DB04846, DB00567, DB09063, DB00439, DB00185, DB06777, DB00446, DB00475, DB00608, DB01114, DB00856, DB00477, DB00356, DB00169, DB01410, DB01166, DB00501, DB01012, DB00537, DB00604, DB00215, DB01211, DB00283, DB04920, DB01190, DB00349, DB00845, DB00636, DB00882, DB01242, DB01068, DB00575, DB00758, DB00628, DB01559, DB00257, DB00363, DB09065, DB05239, DB00907, DB00318, DB01394, DB00872, DB00286, DB01380, DB08865, DB00924, DB00531, DB00091, DB00987, DB08912, DB09102, DB01764, DB01406, DB01219, DB06292, DB00250, DB00496, DB01264, DB09183, DB01254, DB00694, DB01609, DB11921, DB00705, DB01151, DB06700, DB01234, DB04856, DB00514, DB00647, DB00829, DB00586, DB00485, DB00255, DB01396, DB00390, DB01551, DB00320, DB00343, DB01093, DB00280, DB00822, DB01248, DB00204, DB00757, DB08930, DB01184, DB00843, DB00869, DB01142, DB00997, DB00254, DB00470, DB04855, DB01395, DB01126, DB01127, DB00625, DB00216, DB09039, DB09101, DB00584, DB08899, DB00751, DB00668, DB00700, DB00153, DB01049, DB01253, DB00696, DB00530, DB00199, DB01175, DB09119, DB00736, DB01215, DB00783, DB01196, DB00655, DB04574, DB00402, DB00898, DB00977, DB00593, DB01466, DB00294, DB00773, DB01628, DB06414, DB01590, DB00990, DB00973, DB00426, DB00949, DB01023, DB01039, DB00813, DB06702, DB01216, DB08868, DB04908, DB00301, DB00196, DB00180, DB01544, DB00324, DB00472, DB00690, DB00499, DB08906, DB00588, DB01095, DB00176, DB01319, DB06717, DB01320, DB00947, DB00674, DB00317, DB01241, DB01067, DB01016, DB08909, DB00889, DB00365, DB00400, DB01170, DB01018, DB01218, DB00502, DB01159, DB01355, DB05381, DB01275, DB00956, DB00769, DB00741, DB00327, DB06789, DB09053, DB11737, DB09054, DB01181, DB04946, DB00619, DB00458, DB00724, DB05039, DB00808, DB00224, DB00332, DB01029, DB00762, DB06636, DB00951, DB00883, DB01020, DB00270, DB01167, DB09083, DB08820, DB00602, DB04845, DB09570, DB01321, DB01221, DB01587, DB06738, DB01026, DB00448, DB01259, DB06685, DB09078, DB00528, DB01006, DB01002, DB06282, DB01137, DB01227, DB08918, DB00367, DB13139, DB00451, DB00281, DB08882, DB00589, DB08827, DB01206, DB00836, DB01601, DB00455, DB04871, DB00678, DB00227, DB08933, DB09280, DB06708, DB08815, DB08932, DB04835, DB00643, DB00603, DB00358, DB00814, DB01071, DB04817, DB00333, DB04833, DB00703, DB00763, DB00553, DB01028, DB09543, DB00353, DB00959, DB06710, DB00916, DB01011, DB00379, DB06148, DB01388, DB01110, DB00683, DB00834, DB08893, DB00370, DB00648, DB01204, DB00745, DB00471, DB00295, DB00688, DB00607, DB09049, DB01183, DB00731, DB01149, DB00220, DB09048, DB00238, DB00622, DB02701, DB00184, DB01115, DB04868, DB06712, DB00393, DB00401, DB01595, DB01054, DB00435, DB00717, DB01059, DB00957, DB09389, DB00540, DB00334, DB09074, DB00768, DB00338, DB00904, DB04911, DB01083, DB01173, DB09330, DB04938, DB00842, DB00776, DB00239, DB01062, DB00497, DB01192, DB01229, DB09073, DB01267, DB00377, DB06603, DB00213, DB00617, DB01384, DB08439, DB00910, DB09297, DB06589, DB00082, DB00738, DB00312, DB08883, DB01186, DB01074, DB04930, DB00850, DB00454, DB03783, DB00780, DB01174, DB00925, DB00946, DB00812, DB00252, DB01085, DB00337, DB01100, DB01132, DB01621, DB04977, DB01179, DB08910, DB08901, DB01263, DB05478, DB01411, DB01708, DB06209, DB00175, DB01588, DB01058, DB00860, DB00635, DB01087, DB00794, DB01032, DB00433, DB00396, DB01131, DB00420, DB01182, DB00818, DB09396, DB00571, DB00339, DB00545, DB01589, DB01224, DB01103, DB00908, DB00468, DB01369, DB01129, DB00481, DB00980, DB00863, DB00243, DB00234, DB08896, DB00912, DB02709, DB01256, DB00615, DB04934, DB01045, DB01201, DB01220, DB08864, DB06155, DB08931, DB00734, DB00503, DB06228, DB00989, DB00533, DB09291, DB01301, DB06176, DB00268, DB00296, DB01098, DB05271, DB00778, DB12332, DB06201, DB01698, DB08877, DB06654, DB01001, DB00938, DB01232, DB06335, DB01037, DB11362, DB06144, DB01104, DB01236, DB01105, DB00203, DB06207, DB06290, DB00641, DB00877, DB01261, DB06268, DB01591, DB09143, DB00398, DB06145, DB01323, DB00708, DB00359, DB01015, DB00259, DB01138, DB00263, DB01268, DB00864, DB00820, DB00675, DB00706, DB01349, DB05521, DB00976, DB00231, DB00853, DB06287, DB00444, DB00857, DB00342, DB04905, DB00624, DB00759, DB00277, DB00599, DB04572, DB00906, DB08816, DB00208, DB00911, DB01007, DB01409, DB00932, DB08895, DB08811, DB01036, DB06212, DB00273, DB01030, DB00539, DB05109, DB00193, DB08911, DB00752, DB05773, DB00656, DB00755, DB00620, DB00897, DB00347, DB00440, DB00726, DB00197, DB01361, DB06267, DB08867, DB00580, DB00313, DB05294, DB03701, DB00862, DB08881, DB11581, DB00285, DB00661, DB09082, DB06684, DB00570, DB00541, DB00309, DB00361, DB08828, DB00582, DB09068, DB00682, DB01392, DB00549, DB00943, DB00962, DB00495, DB00744, DB00246, DB00425, DB04828, DB00909, DB01198,
ChEMBL ID CHEMBL340
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human immunodeficiency virus 1
Virus Short Name HIV1
Order Unassigned
Virus Family Retroviridae
Virus Subfamily Orthoretrovirinae
Genus Lentivirus
Species Human immunodeficiency virus 1
Host Vertebrates
Cell Tropism CD4+ T cells, macrophages and dendritic cells
Associated Disease Acquired immunodeficiency syndrome
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae

Publication Information

Paper Title Genome-scale RNAi screen for host factors required for HIV replication
Author's Name Honglin Zhou, Min Xu, Qian Huang, Adam T. Gates, Xiaohua D. Zhang, John C. Castle, Erica Stec, Marc Ferrer, Berta Strulovici, Daria J. Hazuda, and Amy S. Espeseth
Journal Name Cell Host and Microbe
Pubmed ID 18976975
Abstract Human immunodeficiency virus (HIV)-1 depends on the host cell machinery to support its replication. To discover cellular factors associated with HIV-1 replication, we conducted a genome-scale siRNA screen, revealing more than 311 host factors, including 267 that were not previously linked to HIV. Surprisingly, there was little overlap between these genes and the HIV dependency factors described recently. However, an analysis of the genes identified in both screens revealed overlaps in several of the associated pathways or protein complexes, including the SP1/mediator complex and the NF-kappaB signaling pathway. cDNAs for a subset of the identified genes were used to rescue HIV replication following knockdown of the cellular mRNA providing strong evidence that the following six genes are previously uncharacterized host factors for HIV: AKT1, PRKAA1, CD97, NEIL3, BMP2K, and SERPINB6. This study highlights both the power and shortcomings of large scale loss-of-function screens in discovering host-pathogen interactions.
Used Model HeLa cells
DOI 10.1016/j.chom.2008.10.004