| Gene Name | STAT2 |
| HF Protein Name | Signal transducer and activator of transcription 2 |
| HF Function | Anti viral protein |
| Uniprot ID | P52630 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 6773 |
| Host Factor (HF) Name in Paper | STAT2 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000170581 |
| Ensemble Transcript | ENST00000314128 [P52630-3];ENST00000557235 [P52630-4] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000981, GO:0001932, GO:0003677, GO:0004871, GO:0005654, GO:0005829, GO:0005886, GO:0006351, GO:0006357, GO:0007259, GO:0016032, GO:0019221, GO:0042802, GO:0044389, GO:0051607, GO:0060337, GO:0060338, GO:0090140, |
| MINT ID | P52630 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 600556 |
| PANTHER ID | PTHR11801 |
| PDB ID(s) | 2KA4, |
| pfam ID | PF00017, PF12188, PF01017, PF02864, PF02865, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human adenovirus 3 |
| Virus Short Name | HAdV-5 |
| Order | Unassigned |
| Virus Family | Adenoviridae |
| Virus Subfamily | N.A. |
| Genus | Mastadenovirus |
| Species | Human mastadenovirus C |
| Host | Human, mammals |
| Cell Tropism | Epithelial cells |
| Associated Disease | Very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. usually mild respiratory, gastrointestinal and eye infections. |
| Mode of Transmission | Respiratory, fecal-oral |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/93/adenoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Adenoviridae |
| Paper Title | STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control |
| Author's Name | Karoly Toth, Sang R. Lee, Baoling Ying, Jacqueline F. Spencer, Ann E. Tollefson, John E. Sagartz, Il-Keun Kong, Zhongde Wang William S. M. Wold |
| Journal Name | PLOS Pathogens |
| Pubmed ID | 26291525 |
| Abstract | Human adenoviruses have been studied extensively in cell culture and have been a model for studies in molecular, cellular, and medical biology. However, much less is known about adenovirus replication and pathogenesis in vivo in a permissive host because of the lack of an adequate animal model. Presently, the most frequently used permissive immunocompetent animal model for human adenovirus infection is the Syrian hamster. Species C human adenoviruses replicate in these animals and cause pathology that is similar to that seen with humans. Here, we report findings with a new Syrian hamster strain in which the STAT2 gene was functionally knocked out by site-specific gene targeting. Adenovirus-infected STAT2 knockout hamsters demonstrated an accentuated pathology compared to the wild-type control animals, and the virus load in the organs of STAT2 knockout animals was 100- to 1000-fold higher than that in wild-type hamsters. Notably, the adaptive immune response to adenovirus is not adversely affected in STAT2 knockout hamsters, and surviving hamsters cleared the infection by 7 to 10 days post challenge. We show that the Type I interferon pathway is disrupted in these hamsters, revealing the critical role of interferon-stimulated genes in controlling adenovirus infection. This is the first study to report findings with a genetically modified Syrian hamster infected with a virus. Further, this is the first study to show that the Type I interferon pathway plays a role in inhibiting human adenovirus replication in a permissive animal model. Besides providing an insight into adenovirus infection in humans, our results are also interesting from the perspective of the animal model: STAT2 knockout Syrian hamster may also be an important animal model for studying other viral infections, including Ebola-, hanta-, and dengue viruses, where Type I interferon-mediated innate immunity prevents wild type hamsters from being effectively infected to be used as animal models. |
| Used Model | A549 and HEK293 cells |
| DOI | 10.1371/journal.ppat.1005084 |
