| Gene Name | SDC2 |
| HF Protein Name | Syndecan-2 |
| HF Function | Involves in HTLV-1 Entry |
| Uniprot ID | P34741 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 6383 |
| Host Factor (HF) Name in Paper | HSPG |
| Gene synonyms | HSPG1 |
| Ensemble Gene ID | ENSG00000169439 |
| Ensemble Transcript | ENST00000302190 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001523, GO:0005788, GO:0005796, GO:0005886, GO:0006024, GO:0006027, GO:0008218, GO:0009986, GO:0016021, GO:0016477, GO:0030165, GO:0030203, GO:0031012, GO:0042802, GO:0043202, GO:0043687, GO:0044267, GO:0048013, GO:0048813, GO:0048814, GO:0050900, |
| MINT ID | P34741 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 142460 |
| PANTHER ID | PTHR10915;PTHR10915:SF6 |
| PDB ID(s) | N.A., |
| pfam ID | PF01034, |
| Drug Bank ID | DB00020, |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human T-lymphotropic virus1 |
| Virus Short Name | HTLV-I |
| Order | Unassigned |
| Virus Family | Retroviridae |
| Virus Subfamily | Orthoretrovirinae |
| Genus | Deltaretrovirus |
| Species | Human T-lymphotropic virus 1 |
| Host | Vertebrates |
| Cell Tropism | Lymphocytes |
| Associated Disease | Adult t-cell leukemia |
| Mode of Transmission | Sexual contact, maternal-neonatal |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae |
| Paper Title | Heparan sulfate proteoglycans mediate attachment and entry of human T-Cell leukemia virus type 1 virions into CD4+ T cells |
| Author's Name | Kathryn S. Jones, Cari Petrow-Sadowski, Daniel C. Bertolette, Ying Huang, and Francis W. Ruscetti |
| Journal Name | Journal Of Virology |
| Pubmed ID | 16188972 |
| Abstract | Heparan sulfate proteoglycans (HSPGs) are used by a number of viruses to facilitate entry into host cells. For the retrovirus human T-cell leukemia virus type 1 (HTLV-1), it has recently been reported that HSPGs are critical for efficient binding of soluble HTLV-1 SU and the entry of HTLV pseudotyped viruses into non-T cells. However, the primary in vivo targets of HTLV-1, CD4(+) T cells, have been reported to express low or undetectable levels of HSPGs. For this study, we reexamined the expression of HSPGs in CD4(+) T cells and examined their role in HTLV-1 attachment and entry. We observed that while quiescent primary CD4(+) T cells do not express detectable levels of HSPGs, HSPGs are expressed on primary CD4(+) T cells following immune activation. Enzymatic modification of HSPGs on the surfaces of either established CD4(+) T-cell lines or primary CD4(+) T cells dramatically reduced the binding of both soluble HTLV-1 SU and HTLV-1 virions. HSPGs also affected the efficiency of HTLV-1 entry, since blocking the interaction with HSPGs markedly reduced both the internalization of HTLV-1 virions and the titer of HTLV-1 pseudotyped viral infection in CD4(+) T cells. Thus, HSPGs play a critical role in the binding and entry of HTLV-1 into CD4(+) T cells. |
| Used Model | MOLT4 and SupT1 cell lines |
| DOI | 10.1128/JVI.79.20.12692-12702.2005 |
