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Virus Details


VHFID6568

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name TNF
HF Protein Name Tumor necrosis factor
HF Function Antiviral protein
Uniprot ID P01375
Protein Sequence View Fasta Sequence
NCBI Gene ID 7124
Host Factor (HF) Name in Paper TNF-alpha
Gene synonyms TNFA TNFSF2
Ensemble Gene ID ENSG00000204490
Ensemble Transcript ENST00000376122;ENST00000383496;ENST00000412275;ENST00000420425;ENST00000443707;ENST00000448781;ENST00000449264
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000060, GO:0000122, GO:0000165, GO:0000185, GO:0000187, GO:0001819, GO:0001891, GO:0001934, GO:0001937, GO:0002020, GO:0002439, GO:0002740, GO:0002876, GO:0002925, GO:0005125, GO:0005164, GO:0005576, GO:0005615, GO:0005886, GO:0005887, GO:0006006, GO:0006919, GO:0006954, GO:0006959, GO:0007249, GO:0007254, GO:0008625, GO:0008630, GO:0009615, GO:0009651, GO:0009897, GO:0009986, GO:0010628, GO:0010629, GO:0010693, GO:0010803, GO:0010888, GO:0019221, GO:0030198, GO:0030316, GO:0030730, GO:0030866, GO:0031334, GO:0031622, GO:0031663, GO:0032715, GO:0032722, GO:0032729, GO:0032755, GO:0032757, GO:0032800, GO:0033138, GO:0033209, GO:0034116, GO:0035509, GO:0042346, GO:0042802, GO:0043065, GO:0043068, GO:0043122, GO:0043123, GO:0043242, GO:0043243, GO:0043280, GO:0043406, GO:0043491, GO:0043507, GO:0044130, GO:0044212, GO:0045071, GO:0045080, GO:0045121, GO:0045416, GO:0045429, GO:0045599, GO:0045662, GO:0045668, GO:0045672, GO:0045732, GO:0045785, GO:0045860, GO:0045892, GO:0045893, GO:0,
MINT ID P01375
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 191160
PANTHER ID PTHR11471:SF23
PDB ID(s) 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 4Y6O, 5M2I, 5M2J, 5M2M, 5MU8, 5TSW, 5UUI, 5WUX,
pfam ID PF00229,
Drug Bank ID DB05250, DB00051, DB04956, DB05879, DB01427, DB05676, DB05066, DB08904, DB00608, DB01407, DB05744, DB05869, DB05758, DB00668, DB00005, DB01296, DB06674, DB05767, DB00065, DB02325, DB05303, DB05218, DB08910, DB01411, DB00852, DB05412, DB05207, DB01041, DB05470, DB05017,
ChEMBL ID CHEMBL1825
Organism Homo sapiens (Human)

Pathogen Information

Virus Name JC Virus
Virus Short Name JC
Order Unassigned
Virus Family Polyomaviridae
Virus Subfamily N.A.
Genus Polyomavirus
Species JC polyomavirus
Host Mammals, human
Cell Tropism Respiratory system, kidneys, or brain
Associated Disease Progressive multifocal leukoencephalopathy
Mode of Transmission N.A.
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/129/polyomaviridae
Virus Host DB link N.A.

Publication Information

Paper Title Role for tumor necrosis factor-alpha in JC virus reactivation and progressive multifocal leukoencephalopathy
Author's Name Hassen S. Wollebo, Mahmut Safak, Luis Del Valle, Kamel Khalili and Martyn K. White
Journal Name Journal Of Neuroimmunology
Pubmed ID 21185609
Abstract JCV causes the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML). After primary infection, JCV persists in a latent state, where viral protein expression and replication are not detectable. NF-κB and C/EBPbeta regulate the JCV promoter via a control element, κB, suggesting proinflammatory cytokines may reactivate JCV to cause PML, e.g., in HIV-1/AIDS. Since HIV-1 induces cytokines in brain, including TNF-alpha, we examined a role for TNF-alpha in JCV regulation. TNF-alpha stimulated both early and late JCV transcription. Further, the κB element conferred TNF-alpha response to a heterologous promoter. Immunohistochemistry of HIV+/PML revealed robust labeling for TNF-alpha and TNFR-1. These data suggest TNF-alpha stimulation of κB may contribute to JCV reactivation in HIV+/PML.
Used Model TC620 cells
DOI 10.1016/j.jneuroim.2010.11.013