| Gene Name | IRF7 |
| HF Protein Name | Interferon regulatory factor 7 |
| HF Function | Antiviral protein |
| Uniprot ID | Q92985 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3665 |
| Host Factor (HF) Name in Paper | IRF7 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000185507 |
| Ensemble Transcript | ENST00000330243 [Q92985-4];ENST00000348655 [Q92985-2];ENST00000397566 [Q92985-4];ENST00000397574 [Q92985-1];ENST00000469048 [Q92985-3];ENST00000533182 [Q92985-3];ENST00000612534 [Q92985-4];ENST00000621391 [Q92985-1];ENST00000632827 [Q92985-4];ENST00000633274 [Q92985-3];ENST00000633943 [Q92985-2];ENST00000634105 [Q92985-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000122, GO:0000979, GO:0000981, GO:0000982, GO:0002819, GO:0003677, GO:0005634, GO:0005654, GO:0005737, GO:0005829, GO:0006366, GO:0006974, GO:0009615, GO:0010008, GO:0016064, GO:0019043, GO:0032479, GO:0032481, GO:0032607, GO:0032608, GO:0032727, GO:0032728, GO:0034124, GO:0034127, GO:0035666, GO:0039530, GO:0045087, GO:0045351, GO:0045655, GO:0045893, GO:0045944, GO:0050776, GO:0051607, GO:0060333, GO:0060337, GO:0060340, GO:2000110, |
| MINT ID | Q92985 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605047 |
| PANTHER ID | PTHR11949 |
| PDB ID(s) | 2O61, |
| pfam ID | PF00605, PF10401, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Lymphocytic choriomeningitis virus |
| Virus Short Name | LCMV |
| Order | Unassigned |
| Virus Family | Arenaviridae |
| Virus Subfamily | N.A. |
| Genus | Mammarenavirus |
| Species | Lymphocytic choriomeningitis virus |
| Host | Vertebrates |
| Cell Tropism | Macrophages |
| Associated Disease | Encephalitis |
| Mode of Transmission | Sexual contact, blood, breast feeding |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=arena |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/203/arenaviridae |
| Virus Host DB link | N.A. |
| Paper Title | IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus |
| Author's Name | Wen Li, Markus J. Hofer, So Ri Jung, Sue-Ling Lim, Iain L. Campbell |
| Journal Name | Journal Of Virology |
| Pubmed ID | 22065774 |
| Abstract | Following systemic infection with lymphocytic choriomeningitis virus (LCMV), STAT1 knockout (KO) mice but not wild-type, STAT2 KO, IRF9 KO, or IFNAR KO mice develop lethal disease perpetrated by CD4(+) T cells. IRF7 is a key transcriptional activator of type I IFN (IFN-I) during LCMV infection. Here, the role of IRF7 in the lethal host response to LCMV infection in STAT1 KO mice was examined. In contrast to STAT1 KO mice, STAT1/IRF7 double KO (DKO) mice survived LCMV infection with a reduced immune pathology in key organs, such as the liver and spleen. However, similar to STAT1 KO mice, STAT1/IRF7 DKO mice failed to control LCMV replication and spread. LCMV infection in STAT1 KO mice was associated with a significant elevation in the levels of a number of cytokines in serum, including IFN-Is, but this was largely absent in STAT1/IRF7 DKO mice, which had a modest increase in the levels of gamma interferon and CCL2 only. Since IRF7 is known to be a key transcriptional regulator of IFN-I gene expression, the possible role of IFN-I in lethal disease was examined further. STAT1/IFNAR DKO mice, in contrast to STAT1 KO mice, all survived infection with LCMV and exhibited little tissue immune pathology. Additionally, STAT1KO mice that were deficient for either of the two IFN-I signaling molecules, STAT2 or IRF9, also survived LCMV infection. We conclude that the lethal immune-mediated disease resulting from LCMV infection in STAT1 KO mice is (i) dependent on IRF7-induced IFN-I production and (ii) driven by noncanonical IFN-I signaling via STAT2 and IRF9. |
| Used Model | STAT1 KO mice, STAT2 KO mice, IRF7 KO and IFNAR KO mice |
| DOI | 10.1128/JVI.03117-13 |
