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Virus Details


VHFID6647

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name STAT1
HF Protein Name Signal transducer and activator of transcription 1-alpha/beta
HF Function MV-P binds with the STAT1 and inhibits the JAK/STAT pathway
Uniprot ID P42224
Protein Sequence View Fasta Sequence
NCBI Gene ID 6772
Host Factor (HF) Name in Paper STAT1
Gene synonyms N.A.
Ensemble Gene ID ENSG00000115415
Ensemble Transcript ENST00000361099 [P42224-1];ENST00000392322 [P42224-2];ENST00000409465 [P42224-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000790, GO:0000978, GO:0000979, GO:0000981, GO:0000982, GO:0000983, GO:0001047, GO:0001937, GO:0002053, GO:0002230, GO:0003340, GO:0003690, GO:0003700, GO:0004871, GO:0005164, GO:0005634, GO:0005654, GO:0005730, GO:0005737, GO:0005829, GO:0006351, GO:0007221, GO:0007259, GO:0007584, GO:0008015, GO:0009612, GO:0010742, GO:0016032, GO:0016525, GO:0019221, GO:0019899, GO:0030424, GO:0030425, GO:0031730, GO:0032727, GO:0032869, GO:0032991, GO:0033209, GO:0034097, GO:0035035, GO:0035257, GO:0035456, GO:0035458, GO:0038114, GO:0042393, GO:0042542, GO:0042802, GO:0042803, GO:0042981, GO:0043124, GO:0043434, GO:0044389, GO:0045296, GO:0045648, GO:0045893, GO:0045944, GO:0046725, GO:0048471, GO:0048661, GO:0051591, GO:0051607, GO:0051721, GO:0051770, GO:0060333, GO:0060334, GO:0060337, GO:0060338, GO:0061326, GO:0070102, GO:0070106, GO:0070491, GO:0070757, GO:0071346, GO:0071407, GO:0072136, GO:0072162, GO:0072308, GO:1990841,
MINT ID P42224
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 600555
PANTHER ID PTHR11801
PDB ID(s) 1BF5, 1YVL, 2KA6, 3WWT,
pfam ID PF00017, PF12162, PF01017, PF02864, PF02865,
Drug Bank ID N.A.,
ChEMBL ID CHEMBL6101
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Measles Virus
Virus Short Name MeV
Order Mononegavirales
Virus Family Paramyxoviridae
Virus Subfamily N.A.
Genus Morbilivirus
Species Measles morbillivirus
Host Vertebrates
Cell Tropism N.A.
Associated Disease Fever, rash
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=paramyxo
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/199/paramyxoviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Paramyxoviridae

Publication Information

Paper Title The measles virus phosphoprotein interacts with the linker domain of STAT1
Author's Name Patricia Devaux, Lauren Priniski and Roberto Cattaneo
Journal Name Virology
Pubmed ID 23856440
Abstract The measles virus (MV) phosphoprotein (P) and V proteins block the interferon (IFN) response by impeding phosphorylation of the signal transducer and activator of transcription 1 (STAT1) by the Janus kinase 1 (JAK1). We characterized how STAT1 mutants interact with P and JAK1 phosphorylation. Certain mutants of the linker, the Src-homology 2 domain (SH2), or the transactivation domain had reduced or abolished phosphorylation through JAK1 after IFN treatment. Other mutants, mainly localized in the linker, failed to interact with P as documented by the lack of interference with nuclear translocation. Thus the functional footprint of P on STAT1 localizes mainly to the linker domain; there is also some overlap with the STAT1 phosphorylation functional footprint on the SH2 domain. Based on these observations, we discuss how the MV-P might operate to inhibit the JAK/STAT pathway.
Used Model U3A cells
DOI 10.1016/j.virol.2013.06.019