| Gene Name | Bst2 |
| HF Protein Name | Bone marrow stromal antigen 2 |
| HF Function | BST-2 restricts MMTV release from naturally infected cells |
| Uniprot ID | Q8R2Q8 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 69550 |
| Host Factor (HF) Name in Paper | BST-2 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSMUSG00000046718 |
| Ensemble Transcript | ENSMUST00000051672 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0002737, GO:0005770, GO:0005794, GO:0005886, GO:0008191, GO:0009615, GO:0009986, GO:0016021, GO:0016324, GO:0030308, GO:0030336, GO:0031225, GO:0032956, GO:0034341, GO:0035455, GO:0035456, GO:0045071, GO:0045087, GO:0045121, GO:0051607, GO:1901253, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | PTHR15190 |
| PDB ID(s) | 3NI0, |
| pfam ID | PF16716, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Mus musculus (Mouse) |
| Virus Name | Mouse mammary tumor virus |
| Virus Short Name | MMTV |
| Order | Unassigned |
| Virus Family | Retroviridae |
| Virus Subfamily | Orthoretrovirinae |
| Genus | Gammaretrovirus |
| Species | Mouse mammary tumor virus |
| Host | Vertebrates |
| Cell Tropism | T and B cells located in Peyer?s patches of the gastrointestinal tracts of neonatally infected pups |
| Associated Disease | N.A. |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae |
| Paper Title | Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo |
| Author's Name | Philip H Jones, Harshini V Mehta, Martina Maric, Richard J Roller and Chioma M Okeoma |
| Journal Name | Retrovirology |
| Pubmed ID | 22284121 |
| Abstract | BACKGROUND: Bone marrow stromal cell antigen 2 (BST-2) is a cellular factor that restricts the egress of viruses such as human immunodeficiency virus (HIV-1) from the surface of infected cells, preventing infection of new cells. BST-2 is variably expressed in most cell types, and its expression is enhanced by cytokines such as type I interferon alpha (IFN-alpha). In this present study, we used the beta-retrovirus, mouse mammary tumor virus (MMTV) as a model to examine the role of mouse BST-2 in host infection in vivo. RESULTS: By using RNA interference, we show that loss of BST-2 enhances MMTV replication in cultured mammary tumor cells and in vivo. In cultured cells, BST-2 inhibits virus accumulation in the culture medium, and co-localizes at the cell surface with virus structural proteins. Furthermore, both scanning electron micrograph (SEM) and transmission electron micrograph (TEM) show that MMTV accumulates on the surface of IFNalpha-stimulated cells. CONCLUSIONS: Our data provide evidence that BST-2 restricts MMTV release from naturally infected cells and that BST-2 is an antiviral factor in vivo. |
| Used Model | C57BL/6 and C3H/HeN mice, NMuMG, GR, 3T3 MEF and 293T cells |
| DOI | 10.1186/1742-4690-9-10 |
