| Gene Name | Lta |
| HF Protein Name | Lymphotoxin-alpha |
| HF Function | Antiviral protein |
| Uniprot ID | P09225 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 16992 |
| Host Factor (HF) Name in Paper | LT-alpha |
| Gene synonyms | Tnfb Tnfsf1 |
| Ensemble Gene ID | ENSMUSG00000024402 |
| Ensemble Transcript | ENSMUST00000025266 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001666, GO:0002876, GO:0002925, GO:0005125, GO:0005164, GO:0005615, GO:0005886, GO:0006954, GO:0006959, GO:0007584, GO:0008283, GO:0008284, GO:0009987, GO:0032496, GO:0032729, GO:0042493, GO:0043065, GO:0044130, GO:0048147, GO:0048535, GO:0050830, GO:0060252, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF00229, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Mus musculus (Mouse) |
| Virus Name | Murine gammaherpesvirus 68 |
| Virus Short Name | MHV-68 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Gammaherpesvirinae |
| Genus | Rhadinovirus |
| Species | Murid herpesvirus 68 |
| Host | Murine,mammals |
| Cell Tropism | B lymphocytes |
| Associated Disease | Mononucleosis, associated with environemental diseases: burkitt?s lymphoma nasopharyngeal carcinoma (npc) |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis |
| Author's Name | BONG JOO LEE, SYBIL SANTEE, SIGRID VON GESJEN, CARL F. WARE, AND SALLY R. SARAWAR |
| Journal Name | Journal Of Virology |
| Pubmed ID | 10684295 |
| Abstract | Respiratory challenge with murine gammaherpesvirus 68 (MHV-68) leads to an acute productive infection of the lung and a persistent latent infection in B lymphocytes, epithelia, and macrophages. The virus also induces splenomegaly and an increase in the number of activated CD8 T cells in the circulation. Lymphotoxina-deficient (LTa2/2) mice have no lymph nodes and have disrupted splenic architecture. Surprisingly, in spite of the severe defect in secondary lymphoid tissue, LTa2/2 mice could clear a productive MHV-68 infection, although with delayed kinetics compared to wild-type mice, and could control latent infection. Cytotoxic T-cell activity was comparable in the lungs and spleens of LTa2/2 and wild-type mice. However, splenic gamma interferon responses were substantially reduced in LTa2/2 mice. Furthermore, LTa2/2 mice failed to develop splenomegaly or lymphocytosis. Although germinal centers were absent, LTa2/2 mice were able to class switch and showed significant virus-specific antibody titers. This work demonstrates that organized secondary lymphoid tissue is not an absolute requirement for the generation of immune responses to viral infections. |
| Used Model | LTalpha?/? mice |
| DOI | 10.1128/JVI.74.6.2786-2792.2000 |
