| Gene Name | SMS |
| HF Protein Name | Spermine synthase |
| HF Function | Activates interferon-beta after virus infection |
| Uniprot ID | P52788 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 6611 |
| Host Factor (HF) Name in Paper | SMS |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000102172 |
| Ensemble Transcript | ENST00000379404 [P52788-2];ENST00000404933 [P52788-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005829, GO:0006555, GO:0006595, GO:0006597, GO:0016768, GO:0070062, |
| MINT ID | P52788 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 300105 |
| PANTHER ID | PTHR11558:SF27 |
| PDB ID(s) | 3C6K, 3C6M, |
| pfam ID | PF17284, |
| Drug Bank ID | DB00127, |
| ChEMBL ID | CHEMBL4934 |
| Organism | Homo sapiens (Human) |
| Virus Name | Sendai virus |
| Virus Short Name | SeV |
| Order | Mononegavirales |
| Virus Family | Paramyxoviridae |
| Virus Subfamily | N.A. |
| Genus | Respirovirus |
| Species | Murine respirovirus |
| Host | Mammals |
| Cell Tropism | N.A. |
| Associated Disease | Acute febrile respiratory tract infection |
| Mode of Transmission | Respiratory |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=paramyxo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/199/paramyxoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Paramyxoviridae |
| Paper Title | Genome-wide RNAi screen reveals a new role of a WNT/ CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses |
| Author's Name | Martin Baril, Salwa Es-Saad, Laurent Chatel-Chaix, Karin Fink, Tram Pham, Vale rie-Ann Raymond, Karine Audette, Anne-Sophie Guenier, Jean Duchaine, Marc Servant, Marc Bilodeau, E ric Cohen, Nathalie Grandvaux, Daniel Lamarre |
| Journal Name | PLOS Pathogens |
| Pubmed ID | 23785285 |
| Abstract | To identify new regulators of antiviral innate immunity, we completed the first genome-wide gene silencing screen assessing the transcriptional response at the interferon-beta (IFNB1) promoter following Sendai virus (SeV) infection. We now report a novel link between WNT signaling pathway and the modulation of retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-dependent innate immune responses. Here we show that secretion of WNT2B and WNT9B and stabilization of beta-catenin (CTNNB1) upon virus infection negatively regulate expression of representative inducible genes IFNB1, IFIT1 and TNF in a CTNNB1-dependent effector mechanism. The antiviral response is drastically reduced by glycogen synthase kinase 3 (GSK3) inhibitors but restored in CTNNB1 knockdown cells. The findings confirm a novel regulation of antiviral innate immunity by a canonical-like WNT/CTNNB1 signaling pathway. The study identifies novel avenues for broad-spectrum antiviral targets and preventing immune-mediated diseases upon viral infection. |
| Used Model | HEK 293T and A549 cells |
| DOI | 10.1371/journal.ppat.1003416 |
