| Gene Name | SAMD9 |
| HF Protein Name | Sterile alpha motif domain-containing protein 9 |
| HF Function | Antiviral host factor |
| Uniprot ID | Q5K651 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 54809 |
| Host Factor (HF) Name in Paper | SAMD9 |
| Gene synonyms | C7orf5 DRIF1 KIAA2004 OEF1 |
| Ensemble Gene ID | ENSG00000205413 |
| Ensemble Transcript | ENST00000379958;ENST00000620985 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005737, GO:0005769, GO:0005829, GO:0034058, GO:0043231, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 610455 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF07647, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Myxoma virus |
| Virus Short Name | MYXV |
| Order | Unassigned |
| Virus Family | Poxviridae |
| Virus Subfamily | Chordopoxvirinae |
| Genus | Leporipoxvirus |
| Species | Myxoma virus |
| Host | Lagomorph and squirrels |
| Cell Tropism | N.A. |
| Associated Disease | Myxomatosis |
| Mode of Transmission | Mechanical transmission by arthropods, direct contact or fomites. |
| VIPR DB link | https://www.viprbrc.org/brc/home.spg?decorator=pox |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/74/poxviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Poxviridae |
| Paper Title | SAMD9 Is an innate antiviral host factor with stress response properties that can Be antagonized by poxviruses |
| Author's Name | Jia Liu, Grant McFadden |
| Journal Name | Journal Of Virology |
| Pubmed ID | 25428864 |
| Abstract | We show that SAMD9 is an innate host antiviral stress response element that participates in the formation of antiviral granules. Poxviruses, myxoma virus and vaccinia virus specifically, utilize a virus-encoded host range factor(s), such as a member of the C7L superfamily, to antagonize SAMD9 to prevent granule formation in a eukaryotic initiation factor 2alpha (eIF2alpha)-independent manner. When SAMD9 is stimulated due to failure of the viral antagonism during infection, the resulting antiviral granules exhibit properties different from those of the canonical stress granules. |
| Used Model | HeLa cells |
| DOI | 10.1128/JVI.02262-14 |
