| Gene Name | SDC4 |
| HF Protein Name | Syndecan-4 |
| HF Function | Essential for virus entry |
| Uniprot ID | Q8HZJ6 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 397528 |
| Host Factor (HF) Name in Paper | SDC4 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSSSCG00000038594 |
| Ensemble Transcript | ENSSSCT00000049336 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001843, GO:0005576, GO:0009986, GO:0010762, GO:0016021, GO:0016477, GO:0042060, GO:0042130, GO:0042802, GO:0060122, GO:0070053, GO:1903543, GO:1903553, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | PTHR10915 |
| PDB ID(s) | N.A., |
| pfam ID | PF01034, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Sus scrofa (Pig) |
| Virus Name | Porcine reproductive and respiratory syndrome virus |
| Virus Short Name | PRRSV |
| Order | Nidovirales |
| Virus Family | Arteriviridae |
| Virus Subfamily | N.A. |
| Genus | Porartevirus |
| Species | Porcine reproductive and respiratory syndrome virus |
| Host | Vertebrates |
| Cell Tropism | Primarily it's found in alveolar lung macrophages and macrophages of other tissues, later, is also found in testicular germ cells. |
| Associated Disease | Abortions and respiratory disease |
| Mode of Transmission | Transplacental, saliva, urine, semen and respiratory tract secretions |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/220/arteriviridae |
| Virus Host DB link | N.A. |
| Paper Title | Syndecan-4, a PRRSV attachment factor, mediates PRRSV entry through its interaction with EGFR |
| Author's Name | Rui Wang, Xin Wang, Bo Ni, Chang-chao Huan, Jia-qiang Wu, Li-bin Wen, Ying Liao, Guang-zhi Tong, Chan Ding, Hong-jie Fan, Xiang Mao |
| Journal Name | Biochemical and Biophysical Research Communications |
| Pubmed ID | 27208778 |
| Abstract | The causative agent of porcine reproductive and respiratory syndrome is the PRRS virus (PRRSV), an enveloped, single-stranded and positive-sense RNA virus. The host factors and mechanisms that are involved in PRRSV entry are still largely unknown. In our present studies, we found that syndecan-4, one of the heparan sulfate proteoglycans, plays a critical role in PRRSV entry, especially in PRRSV attachment. Moreover, EGFR interacts with syndecan-4 in MACR-145 cells and disruption of their interaction impaired PRRSV entry. Furthermore, EGFR inhibitor AG1478 or syndecan-4 derived peptide SSTN87-131 inhibited syndecan-4 endocytosis induced by PRRSV entry. Altogether, syndecan-4, a PRRSV attachment factor, mediated PRRSV entry by interacting with EGFR. |
| Used Model | MARC-145 cells |
| DOI | 10.1016/j.bbrc.2016.05.084 |
