| Virus Name | Rabies virus |
| Virus Short Name | RABV |
| Order | Mononegavirales |
| Virus Family | Rhabdoviridae |
| Virus Subfamily | N.A. |
| Genus | Lyssavirus |
| Species | Rabies lyssavirus |
| Host | Human, mammals |
| Cell Tropism | N.A. |
| Associated Disease | Rabies fatal encephalitis |
| Mode of Transmission | Zoonosis, animal bite |
| VIPR DB link | https://www.viprbrc.org/brc/vipr_allSpecies_search.spg?method=SubmitForm&decorator=rhabdo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/201/rhabdoviridae |
| Virus Host DB link | N.A. |
| Paper Title | Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus |
| Author's Name | Christine Tuffereau, Jacqueline Benejean, Danielle Blondel, Brigitte Kieffer and Anne Flamand |
| Journal Name | The EMBO Journal |
| Pubmed ID | 9857182 |
| Abstract | A random-primed cDNA expression library constructed from the mRNA of neuroblastoma cells (NG108) was used to clone a specific rabies virus (RV) receptor. A soluble form of the RV glycoprotein (Gs) was utilized as a ligand to detect positive cells. We identified the murine low-affinity nerve-growth factor receptor, p75NTR. BSR cells stably expressing p75NTR were able to bind Gs and G-expressing lepidopteran cells. The ability of the RV glycoprotein to bind p75NTR was dependent on the presence of a lysine and arginine in positions 330 and 333 respectively of antigenic site III, which is known to control virus penetration into motor and sensory neurons of adult mice. P75NTR-expressing BSR cells were permissive for a non-adapted fox RV isolate (street virus) and nerve growth factor (NGF) decreased this infection. In infected cells, p75NTR associates with the RV glycoprotein and could be precipitated with anti-G monoclonal antibodies. Therefore, p75NTR is a receptor for street RV. |
| Used Model | Sf21 cells |
| DOI | 10.1093/emboj/17.24.7250 |
