| Gene Name | EIF4A1 |
| HF Protein Name | Eukaryotic initiation factor 4A-I |
| HF Function | Required for Sapovirus translation |
| Uniprot ID | P60842 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 1973 |
| Host Factor (HF) Name in Paper | EIF4A |
| Gene synonyms | DDX2A EIF4A |
| Ensemble Gene ID | ENSG00000161960 |
| Ensemble Transcript | ENST00000293831 [P60842-1];ENST00000577269 [P60842-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000289, GO:0000339, GO:0003723, GO:0003725, GO:0003729, GO:0003743, GO:0004004, GO:0004386, GO:0005524, GO:0005737, GO:0005829, GO:0006413, GO:0008135, GO:0010468, GO:0010501, GO:0016020, GO:0016032, GO:0016281, GO:0070062, |
| MINT ID | P60842 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 602641 |
| PANTHER ID | PTHR24031:SF226 |
| PDB ID(s) | 2G9N, 2ZU6, 3EIQ, |
| pfam ID | PF00270, PF00271, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL2052028 |
| Organism | Homo sapiens (Human) |
| Virus Name | Sapovirus |
| Virus Short Name | N.A. |
| Order | Nidovirales |
| Virus Family | Caliciviridae |
| Virus Subfamily | N.A. |
| Genus | Sapovirus |
| Species | Sapporo virus |
| Host | Humans,swine |
| Cell Tropism | N.A. |
| Associated Disease | Gastroenteritis |
| Mode of Transmission | Fecal-oral |
| VIPR DB link | https://www.viprbrc.org/brc/home.spg?decorator=calici |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/253/caliciviridae |
| Virus Host DB link | N.A. |
| Paper Title | The RNA Helicase eIF4A Is Required for Sapovirus Translation |
| Author's Name | Myra Hosmillo Trevor R. Sweeney, Yasmin Chaudhry, Eoin Leen, Stephen Curry, Ian Goodfellow, Kyoung-Oh Cho |
| Journal Name | Journal Of Virology |
| Pubmed ID | 26937032 |
| Abstract | The eukaryotic initiation factor 4A (eIF4A) is a DEAD box helicase that unwinds RNA structure in the 5 untranslated region (UTR) of mRNAs. Here, we investigated the role of eIF4A in porcine sapovirus VPg-dependent translation. Using inhibitors and dominant-negative mutants, we found that eIF4A is required for viral translation and infectivity, suggesting that despite the presence of a very short 5 UTR, eIF4A is required to unwind RNA structure in the sapovirus genome to facilitate virus translation. |
| Used Model | LLC-PK cells |
| DOI | 10.1128/JVI.03174-15 |
