Virus Details


VHFID7328

Host Factor Information

Gene Name KIN
HF Protein Name DNA/RNA-binding protein KIN17
HF Function Inhibits DNA replication
Uniprot ID O60870
Protein Sequence View Fasta Sequence
NCBI Gene ID 22944
Host Factor (HF) Name in Paper Kin17
Gene synonyms BTCD KIN17
Ensemble Gene ID ENSG00000151657
Ensemble Transcript ENST00000379562 [O60870-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0003677, GO:0003690, GO:0003723, GO:0005634, GO:0005654, GO:0005737, GO:0006260, GO:0006281, GO:0006310, GO:0006397, GO:0006479, GO:0006974, GO:0016032, GO:0016363, GO:0032991, GO:0043231, GO:0046872,
MINT ID O60870
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 601720
PANTHER ID PTHR12805
PDB ID(s) 2CKK, 2V1N,
pfam ID PF10357,
Drug Bank ID N.A.,
ChEMBL ID N.A.
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Simian Virus 40
Virus Short Name SV40
Order Unassigned
Virus Family Polyomaviridae
Virus Subfamily N.A.
Genus Betapolyomavirus
Species Simian virus 40
Host Vertebrates
Cell Tropism N.A.
Associated Disease N.A.
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/129/polyomaviridae
Virus Host DB link N.A.

Publication Information

Paper Title Human Kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication
Author's Name Stephen C.Heinrichs, J.AnthonyDeutsch, Beth O.Moore
Journal Name Physiology and Behavior
Pubmed ID 2359749
Abstract When one unflavored, nonprotein diet was available in two differently scented bins, rats fed a protein-free diet over four days ate more from the bin smelling of gluten, ovalbumin, yeast or fibrin, but not soy, casein or lactalbumin, than from the bin smelling of butter. Rats fed a protein-containing diet over the same four-day period had no such preference. This result demonstrates that protein-deprived rats can use odor cues in making their selection of certain proteins. Since the direction, speed, and size of preference for these protein odors, excepting soy, are remarkably similar to those previously observed when rats actually consumed the proteins, olfactory stimuli appear to elicit appropriate protein selection responses independently of other protein quality variables such as taste, texture or nutrient composition.
Used Model Sf9, MRC5-V2 and HEK 293 cells
DOI 10.1016/0031-9384(90)90101-9