| Gene Name | TEAD1 |
| HF Protein Name | Transcriptional enhancer factor TEF-1 |
| HF Function | Stimulates viral transcription |
| Uniprot ID | P28347 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 7003 |
| Host Factor (HF) Name in Paper | TEF-1 |
| Gene synonyms | TCF13 TEF1 |
| Ensemble Gene ID | ENSG00000187079 |
| Ensemble Transcript | ENST00000334310 [P28347-2];ENST00000638666 [P28347-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000981, GO:0000982, GO:0000987, GO:0001085, GO:0001134, GO:0001223, GO:0003677, GO:0003700, GO:0005654, GO:0006367, GO:0035329, GO:0043565, GO:0045893, GO:0045944, GO:0046982, GO:0048568, GO:0065003, GO:0071148, GO:1902895, |
| MINT ID | P28347 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 108985 |
| PANTHER ID | N.A. |
| PDB ID(s) | 2HZD, 3KYS, 4RE1, 4Z8E, 5NNX, |
| pfam ID | PF01285, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Simian Virus 40 |
| Virus Short Name | SV40 |
| Order | Unassigned |
| Virus Family | Polyomaviridae |
| Virus Subfamily | N.A. |
| Genus | Betapolyomavirus |
| Species | Simian virus 40 |
| Host | Mammals, human |
| Cell Tropism | N.A. |
| Associated Disease | N.A. |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/129/polyomaviridae |
| Virus Host DB link | N.A. |
| Paper Title | trans activation of the simian virus 40 late promoter by large T antigen requires binding sites for the cellular transcription factor TEF-1 |
| Author's Name | PAUL CASAZ, REBECCA SUNDSETH AND ULLA HANSENL |
| Journal Name | Journal Of Virology |
| Pubmed ID | 1658359 |
| Abstract | Simian virus 40 (SV40) T antigen stimulates the level of transcription from several RNA polymerase II promoters, including the SV40 late promoter. The mechanism of trans activation appears to be indirect since binding of T antigen to specific DNA sequences is not required. However, specific promoter elements that respond to T antigen have not previously been defined. We identified DNA sequences from the SV40 late promoter whose ability to stimulate transcription is induced by the expression of T antigen. In particular, the Sph I + II motifs of the SV40 enhancer can confer T-antigen inducibility to the normally uninducible herpes simplex virus thymidine kinase gene promoter when multiple copies of the sequence are inserted 5 of the transcription initiation site and TATA sequence. Binding sites for the cellular transcription factor TEF-1 and octamer binding proteins are contained within the Sph I + II motifs, as well as at other positions in the SV40 promoter. To study the role of individual protein-binding sites in trans activation by T antigen, mutations were constructed in various TEF-1 and octamer protein-binding sites of the SV40 late promoter. These mutations did not significantly affect basal promoter activity. However, mutation of all three TEF-1 sites prevented detectable activation by T antigen. DNase I footprinting of the mutated promoters with purified proteins demonstrated that inducibility by T antigen correlated with binding affinity of TEF-1 for the DNA and not with binding affinity of an octamer binding protein. |
| Used Model | CV-1 cells |
| DOI | N.A. |
