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Virus Details


VHFID9125

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name HSPA5
HF Protein Name Endoplasmic reticulum chaperone BiP
HF Function HSPA5 is vital for replication
Uniprot ID P11021
Protein Sequence View Fasta Sequence
NCBI Gene ID 3309
Host Factor (HF) Name in Paper HSPA5
Gene synonyms GRP78
Ensemble Gene ID ENSG00000044574
Ensemble Transcript ENST00000324460
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0005509, GO:0005524, GO:0005634, GO:0005739, GO:0005783, GO:0005788, GO:0005789, GO:0005790, GO:0005793, GO:0005886, GO:0005925, GO:0006983, GO:0006987, GO:0009986, GO:0010976, GO:0016020, GO:0016887, GO:0019899, GO:0019904, GO:0021589, GO:0021680, GO:0021762, GO:0030176, GO:0030182, GO:0030335, GO:0030433, GO:0030496, GO:0030512, GO:0030968, GO:0031398, GO:0031625, GO:0032991, GO:0034663, GO:0034975, GO:0035437, GO:0035690, GO:0036498, GO:0036499, GO:0036500, GO:0042149, GO:0042220, GO:0042470, GO:0043022, GO:0043066, GO:0043209, GO:0045296, GO:0051082, GO:0051087, GO:0051402, GO:0051787, GO:0060904, GO:0070062, GO:0071236, GO:0071277, GO:0071287, GO:0071320, GO:0071353, GO:0071480, GO:0090074, GO:0097501, GO:1901998, GO:1903891, GO:1903894, GO:1903895, GO:1903897, GO:1904313, GO:1990090, GO:1990440,
MINT ID P11021
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 138120
PANTHER ID PTHR19375
PDB ID(s) 3IUC, 3LDL, 3LDN, 3LDO, 3LDP, 5E84, 5E85, 5E86, 5EVZ, 5EX5, 5EXW, 5EY4, 5F0X, 5F1X, 5F2R, 6ASY,
pfam ID PF00012,
Drug Bank ID DB00945, DB00025,
ChEMBL ID CHEMBL1781865
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Zaire ebolavirus
Virus Short Name ZEBOV
Order Bunyavirales
Virus Family Filoviridae
Virus Subfamily N.A.
Genus Ebolavirus
Species Zaire ebolavirus
Host Bats, human and primates
Cell Tropism N.A.
Associated Disease Hemorragic fever
Mode of Transmission Zoonosis, contact with body fluids
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=filo
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/197/filoviridae
Virus Host DB link N.A.

Publication Information

Paper Title HSPA5 is an essential host factor for Ebola virus infection
Author's Name St. Patrick Reid, Amy C. Shurtleff, Julie A. Costantino, Sarah R. Tritsch, Cary Retterer, Kevin B. Spurgers, Sina Bavari
Journal Name Antiviral Research
Pubmed ID 25017472
Abstract Development of novel strategies targeting the highly virulent ebolaviruses is urgently required. A proteomic study identified the ER chaperone HSPA5 as an ebolavirus-associated host protein. Here, we show using the HSPA5 inhibitor (-)- epigallocatechin gallate (EGCG) that the chaperone is essential for virus infection, thereby demonstrating a functional significance for the association. Furthermore, in vitro and in vivo gene targeting impaired viral replication and protected animals in a lethal infection model. These findings demonstrate that HSPA5 is vital for replication and can serve as a viable target for the design of host-based countermeasures.
Used Model HeLa and 293T cells
DOI 10.1016/j.antiviral.2014.07.004