| Gene Name | HAVCR1 |
| HF Protein Name | Hepatitis A virus cellular receptor 1 |
| HF Function | Essential for virus entry |
| Uniprot ID | Q96D42 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 26762 |
| Host Factor (HF) Name in Paper | TIM1 |
| Gene synonyms | KIM1 TIM1 TIMD1 |
| Ensemble Gene ID | ENSG00000113249 |
| Ensemble Transcript | ENST00000339252;ENST00000523175 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0016021, GO:0031514, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 606518 |
| PANTHER ID | N.A. |
| PDB ID(s) | 5DZO, 5F70, |
| pfam ID | PF07686, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Zaire ebolavirus |
| Virus Short Name | ZEBOV |
| Order | Bunyavirales |
| Virus Family | Filoviridae |
| Virus Subfamily | N.A. |
| Genus | Ebolavirus |
| Species | Zaire ebolavirus |
| Host | Bats, human and primates |
| Cell Tropism | N.A. |
| Associated Disease | Hemorragic fever |
| Mode of Transmission | Zoonosis, contact with body fluids |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=filo |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/197/filoviridae |
| Virus Host DB link | N.A. |
| Paper Title | T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus |
| Author's Name | Andrew S. Kondratowicz, Nicholas J. Lennemann, Patrick L. Sinn, Robert A. Davey, Catherine L. Hunt, Sven Moller-Tank, David K. Meyerholz, Paul Rennert, Robert F. Mullins, Melinda Brindley, Lindsay M. Sandersfeld, Kathrina Quinn, Melodie Weller, Paul B. McCray Jr., John Chiorini, and Wendy Maury |
| Journal Name | PNAS |
| Pubmed ID | 21536871 |
| Abstract | The glycoproteins (GP) of enveloped viruses facilitate entry into the host cell by interacting with specific cellular receptors. Despite extensive study, a cellular receptor for the deadly filoviruses Ebolavirus and Marburgvirus has yet to be identified and characterized. Here, we show that T-cell Ig and mucin domain 1 (TIM-1) binds to the receptor binding domain of the Zaire Ebola virus (EBOV) glycoprotein, and ectopic TIM-1 expression in poorly permissive cells enhances EBOV infection by 10- to 30-fold. Conversely, reduction of cell-surface expression of TIM-1 by RNAi decreased infection of highly permissive Vero cells. TIM-1 expression within the human body is broader than previously appreciated, with expression on mucosal epithelia from the trachea, cornea, and conjunctiva--tissues believed to be important during in vivo transmission of filoviruses. Recognition that TIM-1 serves as a receptor for filoviruses on these mucosal epithelial surfaces provides a mechanistic understanding of routes of entry into the human body via inhalation of aerosol particles or hand-to-eye contact. ARD5, a monoclonal antibody against the IgV domain of TIM-1, blocked EBOV binding and infection, suggesting that antibodies or small molecules directed against this cellular receptor may provide effective filovirus antivirals. |
| Used Model | NCI-60 cell line |
| DOI | 10.1073/pnas.1019030108 |
