Download Help

Virus Details


VHFID9862

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name PARP1
HF Protein Name Poly (ADP-ribose) polymerase 1
HF Function required for virus infection
Uniprot ID P09874
Protein Sequence View Fasta Sequence
NCBI Gene ID 142
Host Factor (HF) Name in Paper PARP1
Gene synonyms ADPRT PPOL
Ensemble Gene ID ENSG00000143799
Ensemble Transcript ENST00000366794.10
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000723, GO:0000781, GO:0000785, GO:0003677, GO:0003682, GO:0003684, GO:0003723, GO:0003950, GO:0005634, GO:0005635, GO:0005654, GO:0005667, GO:0005730, GO:0005739, GO:0005829, GO:0006281, GO:0006302, GO:0006366, GO:0006915, GO:0006974, GO:0007005, GO:0007179, GO:0008270, GO:0010332, GO:0010613, GO:0016020, GO:0016051, GO:0016540, GO:0016604, GO:0016779, GO:0019899, GO:0019901, GO:0023019, GO:0030225, GO:0030331, GO:0030592, GO:0031491, GO:0031625, GO:0032042, GO:0032786, GO:0032869, GO:0032880, GO:0032991, GO:0032993, GO:0033148, GO:0034244, GO:0034599, GO:0034644, GO:0035861, GO:0036211, GO:0042802, GO:0042803, GO:0042826, GO:0043123, GO:0043504, GO:0043596, GO:0045087, GO:0045188, GO:0045824, GO:0045892, GO:0045944, GO:0046697, GO:0050790, GO:0051287, GO:0051901, GO:0060391, GO:0060545, GO:0061629, GO:0070212, GO:0070213, GO:0070412, GO:0071168, GO:0071294, GO:0071932, GO:0090734, GO:0140294, GO:0140537, GO:0140805, GO:0140806, GO:0140807, GO:0140808, GO:0140815, GO:0140816, GO:0140817, GO:0140822, GO:0160049, GO:1900182, GO:1903376, GO:1903518, GO:1904044, GO:1904178, GO:1904357, GO:1904646, GO:1904762, GO:1905051, GO:1905168, GO:1990090, GO:1990404, GO:1990966, GO:2001170,
MINT ID P09874
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 173870
PANTHER ID PTHR10459;PTHR10459:SF112
PDB ID(s) 1UK0, 1UK1, 1WOK, 2COK, 2CR9, 2CS2, 2DMJ, 2JVN, 2L30, 2L31, 2N8A, 2RCW, 2RD6, 2RIQ, 3GJW, 3GN7, 3L3L, 3L3M, 3OD8, 3ODA, 3ODC, 3ODE, 4AV1, 4DQY, 4GV7, 4HHY, 4HHZ, 4L6S, 4OPX, 4OQA, 4OQB, 4PJT, 4R5W, 4R6E, 4RV6, 4UND, 4UXB, 4XHU, 4ZZZ, 5A00, 5DS3, 5HA9, 5KPN, 5KPO, 5KPP, 5KPQ, 5WRQ, 5WRY, 5WRZ, 5WS0, 5WS1, 5WTC, 5XSR, 5XST, 5XSU, 6BHV, 6GHK, 6M3I, 6NRF, 6NRG, 6NRH, 6NRI, 6NRJ, 6NTU, 6VKK, 6VKO, 6VKQ, 6XVW, 7AAA, 7AAB, 7AAC, 7AAD, 7CMW, 7KK2, 7KK3, 7KK4, 7KK5, 7KK6, 7ONR, 7ONS, 7ONT, 7S68, 7S6H, 7S6M, 7S81, 7SCY, 7SCZ, 8FYY, 8FYZ, 8FZ1, 8G0H, 8HE7, 8HLR, 8JNZ, 8U4W, 9ETQ, 9ETR,
pfam ID PF00533, PF21728, PF00644, PF02877, PF05406, PF00645, PF08063,
Drug Bank ID DB04010, DB03509, DB03072, DB03722, DB03073, DB07787, DB07096, DB07330, DB02498, DB13877, DB02701, DB11793, DB02690, DB09074, DB12332, DB11760, DB00277, DB07232, DB01593, DB14487, DB14533, DB14548,
ChEMBL ID CHEMBL3105
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Nipah Virus
Virus Short Name NiV
Order Mononegavirales
Virus Family Paramyxoviridae
Virus Subfamily N.A.
Genus Henipavirus
Species Nipah henipavirus
Host Vertebrates
Cell Tropism N.A.
Associated Disease Fever and headache
Mode of Transmission Sexual contact, blood, breast feeding
VIPR DB link https://www.viprbrc.org/brc/vipr_search.do?species=Nipah_virus
ICTV DB link https://ictv.global/report/152/paramyxoviridae
Virus Host DB link

Publication Information

Paper Title Nipah Virus-Like Particle Egress Is Modulated by Cytoskeletal and Vesicular Trafficking Pathways: a Validated Particle Proteomics Analysis
Author's Name Gunner P. Johnston, Birgit Bradel-Tretheway, Paul D. Piehowski, Heather M. Brewer, Bom Nae Rin Lee, Nicholas T. Usher, J. Lizbeth Reyes Zamora, Victoria Ortega, Erik M. Contreras, Jeremy R. Teuton, Jason P. Wendler, Keesha M. Matz, Joshua N. Adkins, and Hector C. Aguilara
Journal Name mSystems
Pubmed ID 31551400
Abstract Classified as a biosafety level 4 (BSL4) select agent, Nipah virus (NiV) is a deadly henipavirus in the Paramyxoviridae family, with a nearly 75% mortality rate in humans, underscoring its global and animal health importance. Elucidating the process of viral particle production in host cells is imperative both for targeted drug design and viral particle-based vaccine development. However, little is understood concerning the functions of cellular machinery in paramyxoviral and henipaviral assembly and budding. Recent studies showed evidence for the involvement of multiple NiV proteins in viral particle formation, in contrast to the mechanisms understood for several paramyxoviruses as being reliant on the matrix (M) protein alone. Further, the levels and purposes of cellular factor incorporation into viral particles are largely unexplored for the paramyxoviruses. To better understand the involvement of cellular machinery and the major structural viral fusion (F), attachment (G), and matrix (M) proteins, we performed proteomics analyses on virus-like particles (VLPs) produced from several combinations of these NiV proteins. Our findings indicate that NiV VLPs incorporate vesicular trafficking and actin cytoskeletal factors. The involvement of these biological processes was validated by experiments indicating that the perturbation of key factors in these cellular processes substantially modulated viral particle formation. These effects were most impacted for NiV-F-modulated viral particle formation either autonomously or in combination with other NiV proteins, indicating that NiV-F budding relies heavily on these cellular processes. These findings indicate a significant involvement of the NiV fusion protein, vesicular trafficking, and actin cytoskeletal processes in efficient viral particle formation.
Used Model HEK293T
DOI 10.1128/mSystems.00194-19